| Literature DB >> 24607406 |
Matilde Todaro1, Miriam Gaggianesi2, Veronica Catalano1, Antonina Benfante1, Flora Iovino2, Mauro Biffoni3, Tiziana Apuzzo1, Isabella Sperduti4, Silvia Volpe2, Gianfranco Cocorullo2, Gaspare Gulotta2, Francesco Dieli5, Ruggero De Maria6, Giorgio Stassi7.
Abstract
Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) express CD44v6, which is required for their migration and generation of metastatic tumors. CD44v6 expression is low in primary tumors but demarcated clonogenic CR-CSC populations. Cytokines hepatocyte growth factor (HGF), osteopontin (OPN), and stromal-derived factor 1α (SDF-1), secreted from tumor associated cells, increase CD44v6 expression in CR-CSCs by activating the Wnt/β-catenin pathway, which promotes migration and metastasis. CD44v6(-) progenitor cells do not give rise to metastatic lesions but, when treated with cytokines, acquire CD44v6 expression and metastatic capacity. Importantly, phosphatidylinositol 3-kinase (PI3K) inhibition selectively killed CD44v6 CR-CSCs and reduced metastatic growth. In patient cohorts, low levels of CD44v6 predict increased probability of survival. Thus, the metastatic process in colorectal cancer is initiated by CSCs through the expression of CD44v6, which is both a functional biomarker and therapeutic target.Entities:
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Year: 2014 PMID： 24607406 DOI： 10.1016/j.stem.2014.01.009
Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633