Literature DB >> 2460624

Methotrexate suppresses passive adjuvant arthritis: studies on the metabolism of methotrexate in mononuclear cells derived from normal and adjuvant arthritic rats.

S C Ridge1, K M Ferguson, N Rath, J Galivan, J H Freisheim, A L Oronsky, S S Kerwar.   

Abstract

Passive transfer of adjuvant arthritis by spleen cells is suppressed by methotrexate. Mononuclear cells derived from spleens of normal and adjuvant arthritic Lewis rats were incubated with [3H]-methotrexate and harvested at various periods of time. The amount of methotrexate and its various polyglutamates were quantitated. The results of these studies indicate that the kinetics of uptake of methotrexate by mononuclear cells from normal and adjuvant arthritic rats are similar. However, the amount of methotrexate polyglutamates accumulating in the mononuclear cells of adjuvant arthritic rats was significantly lower than that observed in mononuclear cells derived from normal rats.

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Year:  1988        PMID： 2460624

Source DB:  PubMed          Journal:  J Rheumatol        ISSN： 0315-162X            Impact factor:   4.666


  6 in total

1.  Anti-arthritic activity of the Indian leafy vegetable Cardiospermum halicacabum in Wistar rats and UPLC-QTOF-MS/MS identification of the putative active phenolic components.

Authors:  Ramachandran Jeyadevi; Thilagar Sivasudha; Angappan Rameshkumar; Lakshmanan Dinesh Kumar
Journal:  Inflamm Res       Date:  2012-09-29       Impact factor: 4.575

2.  The effect of methotrexate on lipoxygenase metabolism in neutrophils from rats: in vitro and ex vivo studies.

Authors:  J S Hawkes; L G Cleland; M J James
Journal:  Agents Actions       Date:  1993-11

3.  Differential effects of methotrexate and liposomally conjugated methotrexate in rat adjuvant-induced arthritis.

Authors:  A S Williams; J P Camilleri; N Amos; B D Williams
Journal:  Clin Exp Immunol       Date:  1995-12       Impact factor: 4.330

4.  Long-term treatment of the MRL/lpr mouse with methotrexate and 10-deazaaminopterin.

Authors:  J E Baggott; S L Morgan; L E Freeberg; B B Hudson; W H Vaughn; M Gopal Nair; C L Krumdieck; W J Koopman; R E Gay; S Gay
Journal:  Agents Actions       Date:  1992-01

5.  Treatment of experimental adjuvant arthritis with the combination of methotrexate and lyophilized Enterococcus faecium enriched with organic selenium.

Authors:  J Rovenský; K Svík; M Stancíková; R Istok; L Ebringer; M Ferencík
Journal:  Folia Microbiol (Praha)       Date:  2002       Impact factor: 2.099

6.  Efficacy of Methotrexate on Rat Knee Osteoarthritis Induced by Monosodium Iodoacetate.

Authors:  Yuki Yamanashi; Mika Ohmichi; Yusuke Ohmichi; Tatsunori Ikemoto; Young-Chang Arai; Yohei Maruyama; Shun Otsuka; Shuichi Hirai; Munekazu Naito; Masataka Deie
Journal:  J Inflamm Res       Date:  2021-07-15
  6 in total

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