Literature DB >> 24603272

Intravenous midazolam dose ranges in older patients sedated for oral surgery--a preliminary retrospective cohort study.

M Chauhan1, E Carter1, P Rood1.   

Abstract

AIM: The aim of this study was to investigate differences in the titrated midazolam doses in older patients undergoing oral surgery procedures under intravenous sedation.
METHOD: The records of 50 patients aged 40-92 years who had undergone oral surgery procedures under intravenous sedation at Kings College Hospital between May 2008 and February 2009 were selected at random in each of the age groups: 40, 50, 60, 70 or 80+.Results The mean dose for patients over the age of 70 (2.8 mg) was 50% less than the mean dose for those under the age of 70 (5.7 mg).
CONCLUSIONS: Our study found a correlation between the age of the patient and the dose of midazolam required for sedation before oral surgery procedures, with, on average, older patients requiring less midazolam. A range of doses are required in any age group, but the range decreases as age increases.

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Year:  2014        PMID: 24603272     DOI: 10.1038/sj.bdj.2014.197

Source DB:  PubMed          Journal:  Br Dent J        ISSN: 0007-0610            Impact factor:   1.626


  6 in total

1.  A conscious decision. A review of the use of general anaesthesia and conscious sedation in primary dental care.

Authors:  D Pike
Journal:  SAAD Dig       Date:  2000-07

2.  Recovery of postural stability following conscious sedation with midazolam in the elderly.

Authors:  Toshiaki Fujisawa; Shinobu Suzuki; Keisuke Tanaka; Nobuhito Kamekura; Kazuaki Fukushima; Osamu Kemmotsu
Journal:  J Anesth       Date:  2002       Impact factor: 2.078

3.  Aging increases pharmacodynamic sensitivity to the hypnotic effects of midazolam.

Authors:  J R Jacobs; J G Reves; J Marty; W D White; S A Bai; L R Smith
Journal:  Anesth Analg       Date:  1995-01       Impact factor: 5.108

4.  Effect of age, gender, and obesity on midazolam kinetics.

Authors:  D J Greenblatt; D R Abernethy; A Locniskar; J S Harmatz; R A Limjuco; R I Shader
Journal:  Anesthesiology       Date:  1984-07       Impact factor: 7.892

5.  Intravenous midazolam for upper gastrointestinal endoscopy: a study of 800 consecutive cases relating dose to age and sex of patient.

Authors:  G D Bell; G P Spickett; P A Reeve; A Morden; R F Logan
Journal:  Br J Clin Pharmacol       Date:  1987-02       Impact factor: 4.335

6.  Estimating the need for dental sedation. 1. The Indicator of Sedation Need (IOSN) - a novel assessment tool.

Authors:  P Coulthard; C M Bridgman; L Gough; L Longman; I A Pretty; T Jenner
Journal:  Br Dent J       Date:  2011-09-09       Impact factor: 1.626

  6 in total

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