Masaaki Hori1, Satoshi Tsutsumi2, Yukimasa Yasumoto2, Masanori Ito2, Michimasa Suzuki3, Fumine S Tanaka3, Shinsuke Kyogoku4, Masanobu Nakamura5, Takashi Tabuchi5, Issei Fukunaga6, Yuriko Suzuki7, Koji Kamagata3, Yoshitaka Masutani8, Shigeki Aoki3. 1. Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan. Electronic address: mahori@juntendo.ac.jp. 2. Department of Neurological Surgery, Juntendo University Urayasu Hospital, Chiba, Japan. 3. Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan. 4. Department of Radiology, Juntendo University Urayasu Hospital, Chiba, Japan. 5. Radiology, Yaesu Clinic, Tokyo, Japan. 6. Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan; Department of Health Science, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan. 7. Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan; Philips Electronics Japan, Tokyo, Japan. 8. Department of Radiology, The University of Tokyo Hospital, Tokyo, Japan.
Abstract
INTRODUCTION: We investigated microstructural changes in the spinal cord, separately for white matter and gray matter, in patients with cervical spondylosis by using diffusional kurtosis imaging (DKI). METHODS: We studied 13 consecutive patients with cervical myelopathy (15 affected sides and 11 unaffected sides). After conventional magnetic resonance (MR) imaging, DKI data were acquired by using a 3T MR imaging scanner. Values for fractional anisotropy (FA), apparent diffusion coefficient (ADC), and mean diffusional kurtosis (MK) were calculated and compared between unaffected and affected spinal cords, separately for white matter and gray matter. RESULTS: Tract-specific analysis of white matter in the lateral funiculus showed no statistical differences between the affected and unaffected sides. In gray matter, only MK was significantly lower in the affected spinal cords than in unaffected spinal cords (0.60±0.18 vs. 0.73±0.13, P=0.0005, Wilcoxon's signed rank test). CONCLUSIONS: MK values in the spinal cord may reflect microstructural changes and gray matter damage and can potentially provide more information beyond that obtained with conventional diffusion metrics.
INTRODUCTION: We investigated microstructural changes in the spinal cord, separately for white matter and gray matter, in patients with cervical spondylosis by using diffusional kurtosis imaging (DKI). METHODS: We studied 13 consecutive patients with cervical myelopathy (15 affected sides and 11 unaffected sides). After conventional magnetic resonance (MR) imaging, DKI data were acquired by using a 3T MR imaging scanner. Values for fractional anisotropy (FA), apparent diffusion coefficient (ADC), and mean diffusional kurtosis (MK) were calculated and compared between unaffected and affected spinal cords, separately for white matter and gray matter. RESULTS: Tract-specific analysis of white matter in the lateral funiculus showed no statistical differences between the affected and unaffected sides. In gray matter, only MK was significantly lower in the affected spinal cords than in unaffected spinal cords (0.60±0.18 vs. 0.73±0.13, P=0.0005, Wilcoxon's signed rank test). CONCLUSIONS: MK values in the spinal cord may reflect microstructural changes and gray matter damage and can potentially provide more information beyond that obtained with conventional diffusion metrics.
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