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Literature DB >> 24600515

Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase.

Abstract

Ribonucleotide reductase (RNR), the rate-limiting enzyme in DNA synthesis, catalyzes reduction of the different ribonucleotides to their corresponding deoxyribonucleotides. The crucial role of RNR in DNA synthesis has made it an important target for the development of antiviral and anticancer drugs. Taking account of the recent developments in this field of research, this review focuses on the role of thioredoxin and glutaredoxin systems in the redox reactions of the RNR catalysis.

Entities: Gene

Keywords: DNA synthesis; Glutaredoxin; Replication; Ribonucleotide reductase; Thiol disulfides; Thioredoxin

Year: 2014 PMID： 24600515 PMCID： PMC3942543 DOI： 10.4331/wjbc.v5.i1.68

Source DB: PubMed Journal: World J Biol Chem ISSN： 1949-8454

55 in total

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Authors: Nuno M F S A Cerqueira; Pedro A Fernandes; Maria J Ramos
Journal: Recent Pat Anticancer Drug Discov Date: 2007-01 Impact factor: 4.169

2. Location of the redox-active thiols of ribonucleotide reductase: sequence similarity between the Escherichia coli and Lactobacillus leichmannii enzymes.

Authors: A N Lin; G W Ashley; J Stubbe
Journal: Biochemistry Date: 1987-11-03 Impact factor: 3.162

3. Preclinical toxicity and toxicokinetics of GTI-2040, a phosphorothioate oligonucleotide targeting ribonucleotide reductase R2.

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Journal: Cancer Chemother Pharmacol Date: 2010-10-01 Impact factor: 3.333

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Authors: Arne Holmgren; Rajib Sengupta
Journal: Free Radic Biol Med Date: 2010-09-16 Impact factor: 7.376

5. Inhibition of chlamydial class Ic ribonucleotide reductase by C-terminal peptides from protein R2.

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Journal: J Pept Sci Date: 2011-10-04 Impact factor: 1.905

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Authors: Eleanor W Trotter; Chris M Grant
Journal: EMBO Rep Date: 2003-02 Impact factor: 8.807

7. Toxic effects of acute glutathione depletion by buthionine sulfoximine and dimethylfumarate on murine mammary carcinoma cells.

Authors: L A Dethlefsen; C M Lehman; J E Biaglow; V M Peck
Journal: Radiat Res Date: 1988-05 Impact factor: 2.841

8. Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion.

Authors: Alice Bourdon; Limor Minai; Valérie Serre; Jean-Philippe Jais; Emmanuelle Sarzi; Sophie Aubert; Dominique Chrétien; Pascale de Lonlay; Véronique Paquis-Flucklinger; Hirofumi Arakawa; Yusuke Nakamura; Arnold Munnich; Agnès Rötig
Journal: Nat Genet Date: 2007-05-07 Impact factor: 38.330

Review 9. Glutaredoxin systems.

Authors: Christopher Horst Lillig; Carsten Berndt; Arne Holmgren
Journal: Biochim Biophys Acta Date: 2008-06-18

10. Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication.

Authors: Min-Hyuk Yoo; Xue-Ming Xu; Bradley A Carlson; Andrew D Patterson; Vadim N Gladyshev; Dolph L Hatfield
Journal: PLoS One Date: 2007-10-31 Impact factor: 3.240

33 in total

Review 1. Pyridine Dinucleotides from Molecules to Man.

Authors: Joshua P Fessel; William M Oldham
Journal: Antioxid Redox Signal Date: 2017-07-25 Impact factor: 8.401

2. Glutathione-glutaredoxin is an efficient electron donor system for mammalian p53R2-R1-dependent ribonucleotide reductase.

Authors: Rajib Sengupta; Lucia Coppo; Pradeep Mishra; Arne Holmgren
Journal: J Biol Chem Date: 2019-07-02 Impact factor: 5.157

Review 3. Biochemical mechanisms and therapeutic potential of pseudohalide thiocyanate in human health.

Authors: Joshua D Chandler; Brian J Day
Journal: Free Radic Res Date: 2015-01-28

4. An essential thioredoxin is involved in the control of the cell cycle in the bacterium Caulobacter crescentus.

Authors: Camille V Goemans; François Beaufay; Khadija Wahni; Inge Van Molle; Joris Messens; Jean-François Collet
Journal: J Biol Chem Date: 2018-01-24 Impact factor: 5.157

Review 5. Endothelial Cell Metabolism.

Authors: Guy Eelen; Pauline de Zeeuw; Lucas Treps; Ulrike Harjes; Brian W Wong; Peter Carmeliet
Journal: Physiol Rev Date: 2018-01-01 Impact factor: 37.312

Review 6. The basics of thiols and cysteines in redox biology and chemistry.

Authors: Leslie B Poole
Journal: Free Radic Biol Med Date: 2014-11-27 Impact factor: 7.376

7. Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy.

Authors: Meng Lou; Qian Liu; Guoping Ren; Jiling Zeng; Xueping Xiang; Yongfeng Ding; Qinghui Lin; Tingting Zhong; Xia Liu; Lijun Zhu; Hongyan Qi; Jing Shen; Haoran Li; Jimin Shao
Journal: J Biol Chem Date: 2017-04-14 Impact factor: 5.157

8. Dose-biomarker-response modeling of the anticancer effect of ethaselen in a human non-small cell lung cancer xenograft mouse model.

Authors: Suo-Fu Ye; Jian Li; Shuang-Min Ji; Hui-Hui Zeng; Wei Lu
Journal: Acta Pharmacol Sin Date: 2016-12-05 Impact factor: 6.150

9. A proximity-based in silico approach to identify redox-labile disulfide bonds: The example of FVIII.

Authors: Andrea Arsiccio; Clive Metcalfe; Roberto Pisano; Sanj Raut; Carmen Coxon
Journal: PLoS One Date: 2022-02-07 Impact factor: 3.240

Review 10. NADPH-dependent and -independent disulfide reductase systems.

Authors: Colin G Miller; Arne Holmgren; Elias S J Arnér; Edward E Schmidt
Journal: Free Radic Biol Med Date: 2018-03-30 Impact factor: 7.376