BACKGROUND: Uterine leiomyomata (UL) are the primary indication for hysterectomy and are 2-3 times more common in black than white women. High dietary fat intake has been associated with increased endogenous concentrations of estradiol, a sex steroid hormone that is known to influence UL risk. OBJECTIVE: We assessed the relation of dietary fat intake (total, subtypes, and selected food sources) with UL incidence. DESIGN: Data were from the Black Women's Health Study, a prospective cohort study. Over an 8-y period (2001-2009), 12,044 premenopausal women were followed for a first diagnosis of UL. Diet was assessed via a food-frequency questionnaire in 2001. Cox regression models were used to compute incidence rate ratios (IRRs) and 95% CIs with adjustment for potential confounders. RESULTS: During 75,687 person-years of follow-up, there were 2695 incident UL cases diagnosed by ultrasound (n = 2191) or surgery (n = 504). Intakes of total fat and fat subtypes were not appreciably associated with UL risk overall, although statistically significant associations were observed for specific saturated (inverse) and monounsaturated and polyunsaturated (positive) fatty acids. With respect to polyunsaturated fats, the IRR for the highest compared with lowest quintiles of marine fatty acid intake [the sum of omega-3 (n-3) polyunsaturated fatty acids eicosapentanoic acid, docosapentaenoic acid, and docosahexaenoic acid] was 1.18 (95% CI: 1.05, 1.34; P-trend = 0.005). The IRR for the highest compared with lowest categories of dark-meat fish consumption was 1.13 (95% CI: 1.00, 1.28). CONCLUSIONS: In US black women, the most consistent associations of fat intake with UL were small increases in risk associated with intakes of long-chain omega-3 fatty acids. Future studies are warranted to confirm these findings and elucidate which components of fatty foods, if any, are related to UL risk.
BACKGROUND: Uterine leiomyomata (UL) are the primary indication for hysterectomy and are 2-3 times more common in black than white women. High dietary fat intake has been associated with increased endogenous concentrations of estradiol, a sex steroid hormone that is known to influence UL risk. OBJECTIVE: We assessed the relation of dietary fat intake (total, subtypes, and selected food sources) with UL incidence. DESIGN: Data were from the Black Women's Health Study, a prospective cohort study. Over an 8-y period (2001-2009), 12,044 premenopausal women were followed for a first diagnosis of UL. Diet was assessed via a food-frequency questionnaire in 2001. Cox regression models were used to compute incidence rate ratios (IRRs) and 95% CIs with adjustment for potential confounders. RESULTS: During 75,687 person-years of follow-up, there were 2695 incident UL cases diagnosed by ultrasound (n = 2191) or surgery (n = 504). Intakes of total fat and fat subtypes were not appreciably associated with UL risk overall, although statistically significant associations were observed for specific saturated (inverse) and monounsaturated and polyunsaturated (positive) fatty acids. With respect to polyunsaturated fats, the IRR for the highest compared with lowest quintiles of marine fatty acid intake [the sum of omega-3 (n-3) polyunsaturated fatty acidseicosapentanoic acid, docosapentaenoic acid, and docosahexaenoic acid] was 1.18 (95% CI: 1.05, 1.34; P-trend = 0.005). The IRR for the highest compared with lowest categories of dark-meat fish consumption was 1.13 (95% CI: 1.00, 1.28). CONCLUSIONS: In US black women, the most consistent associations of fat intake with UL were small increases in risk associated with intakes of long-chain omega-3 fatty acids. Future studies are warranted to confirm these findings and elucidate which components of fatty foods, if any, are related to UL risk.
Authors: Lauren A Wise; Rose G Radin; Julie R Palmer; Shiriki K Kumanyika; Deborah A Boggs; Lynn Rosenberg Journal: Am J Clin Nutr Date: 2011-11-09 Impact factor: 7.045
Authors: Stacey A Missmer; Jorge E Chavarro; Susan Malspeis; Elizabeth R Bertone-Johnson; Mark D Hornstein; Donna Spiegelman; Robert L Barbieri; Walter C Willett; Susan E Hankinson Journal: Hum Reprod Date: 2010-03-23 Impact factor: 6.918
Authors: B R Goldin; H Adlercreutz; S L Gorbach; M N Woods; J T Dwyer; T Conlon; E Bohn; S N Gershoff Journal: Am J Clin Nutr Date: 1986-12 Impact factor: 7.045
Authors: P H Gann; C H Hennekens; F M Sacks; F Grodstein; E L Giovannucci; M J Stampfer Journal: J Natl Cancer Inst Date: 1994-02-16 Impact factor: 13.506
Authors: Theodore M Brasky; Amy K Darke; Xiaoling Song; Catherine M Tangen; Phyllis J Goodman; Ian M Thompson; Frank L Meyskens; Gary E Goodman; Lori M Minasian; Howard L Parnes; Eric A Klein; Alan R Kristal Journal: J Natl Cancer Inst Date: 2013-07-10 Impact factor: 13.506
Authors: Keewan Kim; Richard W Browne; Carrie J Nobles; Rose G Radin; Tiffany L Holland; Ukpebo R Omosigho; Matthew T Connell; Torie C Plowden; Brian D Wilcox; Robert M Silver; Neil J Perkins; Enrique F Schisterman; Christina M Nichols; Daniel L Kuhr; Lindsey A Sjaarda; Sunni L Mumford Journal: Epidemiology Date: 2019-11 Impact factor: 4.822
Authors: Holly R Harris; A Heather Eliassen; David R Doody; Kathryn L Terry; Stacey A Missmer Journal: Fertil Steril Date: 2020-07-14 Impact factor: 7.329
Authors: Sunni L Mumford; Richard W Browne; Keewan Kim; Christina Nichols; Brian Wilcox; Robert M Silver; Matthew T Connell; Tiffany L Holland; Daniel L Kuhr; Ukpebo R Omosigho; Neil J Perkins; Rose Radin; Lindsey A Sjaarda; Enrique F Schisterman Journal: J Clin Endocrinol Metab Date: 2018-12-01 Impact factor: 5.958
Authors: Lauren A Wise; Julie R Palmer; Lynn Rosenberg; Stephen A Haddad; Edward A Ruiz-Narváez Journal: Fertil Steril Date: 2016-06-30 Impact factor: 7.329
Authors: Amelia K Wesselink; Birgit Claus Henn; Victoria Fruh; Olivia R Orta; Jennifer Weuve; Russ Hauser; Paige L Williams; Michael D McClean; Andreas Sjodin; Traci N Bethea; Theodore M Brasky; Donna D Baird; Lauren A Wise Journal: Epidemiology Date: 2021-03-01 Impact factor: 4.822