Anwar Hasan Siddiqui1, Rajiv Gulati2, Nazia Tauheed3, Anjum Pervez4. 1. Senior Resident, Department of Physiology, JNMC, AMU , Aligarh, UP., India . 2. Professor, Department of Anesthesia, Jawaharlal Nehru Medical College , Aligarh Muslim University, Aligarh, UP, India . 3. Senior Resident, Department of Physiology, Jawaharlal Nehru Medical College , Aligarh Muslim University, Aligarh, UP, India . 4. Associate Professor, Department of Medicine, Jawaharlal Nehru Medical College , Aligarh Muslim University, Aligarh, UP, India .
Abstract
BACKGROUND: Obesity is associated with increased oxidative stress and lipid peroxidation is thought to play a crucial role in the generation of atherosclerotic lesions of Acute Myocardial Infarction (AMI). METHODS: The case-control study contained 120 subjects divided in two groups, 60 patients with AMI and equal number of age- and sex-matched healthy subjects as controls. Ratio of Waist Circumference (WC) to Hip Circumference (HC) (waist-to-hip ratio) of all the subjects was recorded. Antioxidant status of the individuals was determined by measuring the serum levels of Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD). Estimation of Malondialdehyde (MDA), a marker of lipid peroxidation was used as a surrogate marker of free radical activity. RESULTS: WHR was found to be significantly higher in patients of AMI as compared to controls. MDA levels were significantly high and antioxidants molecules GPx and SOD were significantly decreased in AMI patients as compared with control (p<0.001). WHR correlated positively to serum level of MDA and inversely to the serum level of antioxidant enzymes. CONCLUSION: High Waist-to-hip ratio is associated with high concentrations of malondialdehyde level and low concentration of antioxidant's enzyme. This results in increased oxidative stress, a major causative factor of AMI.
BACKGROUND: Obesity is associated with increased oxidative stress and lipid peroxidation is thought to play a crucial role in the generation of atherosclerotic lesions of Acute Myocardial Infarction (AMI). METHODS: The case-control study contained 120 subjects divided in two groups, 60 patients with AMI and equal number of age- and sex-matched healthy subjects as controls. Ratio of Waist Circumference (WC) to Hip Circumference (HC) (waist-to-hip ratio) of all the subjects was recorded. Antioxidant status of the individuals was determined by measuring the serum levels of Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD). Estimation of Malondialdehyde (MDA), a marker of lipid peroxidation was used as a surrogate marker of free radical activity. RESULTS: WHR was found to be significantly higher in patients of AMI as compared to controls. MDA levels were significantly high and antioxidants molecules GPx and SOD were significantly decreased in AMI patients as compared with control (p<0.001). WHR correlated positively to serum level of MDA and inversely to the serum level of antioxidant enzymes. CONCLUSION: High Waist-to-hip ratio is associated with high concentrations of malondialdehyde level and low concentration of antioxidant's enzyme. This results in increased oxidative stress, a major causative factor of AMI.
Authors: John F Keaney; Martin G Larson; Ramachandran S Vasan; Peter W F Wilson; Izabella Lipinska; Diane Corey; Joseph M Massaro; Patrice Sutherland; Joseph A Vita; Emelia J Benjamin Journal: Arterioscler Thromb Vasc Biol Date: 2003-01-30 Impact factor: 8.311