BACKGROUND: The purpose of this study was to critically review the published evidence concerning adjunctive diagnostic techniques in the diagnosis of oral lesions of unknown malignant potential. METHODS: We conducted a systematic literature review with meta-analysis using PubMed to search for articles published from June 1993 through June 2013 to identify prospective studies evaluating any diagnostic method, with tissue biopsy confirmation, in clinically evident oral lesions of unknown malignant potential. Aggregate weighted totals and SEs for true, false-positive, false-negative, and inadequate results were calculated and compared among subgroups. RESULTS: Forty-eight articles satisfying inclusion criteria were identified. Twenty-five were included in quantitative synthesis. CONCLUSION: Oral cytology holds higher diagnostic value than specialist's oral examination, which holds higher value than in vivo toluidine blue staining. This study does not support the use of computer-aided or liquid-based cytology. Future studies should be designed to test multiple methods in the same patient population to allow direct comparison among various techniques.
BACKGROUND: The purpose of this study was to critically review the published evidence concerning adjunctive diagnostic techniques in the diagnosis of oral lesions of unknown malignant potential. METHODS: We conducted a systematic literature review with meta-analysis using PubMed to search for articles published from June 1993 through June 2013 to identify prospective studies evaluating any diagnostic method, with tissue biopsy confirmation, in clinically evident oral lesions of unknown malignant potential. Aggregate weighted totals and SEs for true, false-positive, false-negative, and inadequate results were calculated and compared among subgroups. RESULTS: Forty-eight articles satisfying inclusion criteria were identified. Twenty-five were included in quantitative synthesis. CONCLUSION: Oral cytology holds higher diagnostic value than specialist's oral examination, which holds higher value than in vivo toluidine blue staining. This study does not support the use of computer-aided or liquid-based cytology. Future studies should be designed to test multiple methods in the same patient population to allow direct comparison among various techniques.
Authors: Timothy J Abram; Pierre N Floriano; Nicolaos Christodoulides; Robert James; A Ross Kerr; Martin H Thornhill; Spencer W Redding; Nadarajah Vigneswaran; Paul M Speight; Julie Vick; Craig Murdoch; Christine Freeman; Anne M Hegarty; Katy D'Apice; Joan A Phelan; Patricia M Corby; Ismael Khouly; Jerry Bouquot; Nagi M Demian; Y Etan Weinstock; Stephanie Rowan; Chih-Ko Yeh; H Stan McGuff; Frank R Miller; Surabhi Gaur; Kailash Karthikeyan; Leander Taylor; Cathy Le; Michael Nguyen; Humberto Talavera; Rameez Raja; Jorge Wong; John T McDevitt Journal: Oral Oncol Date: 2016-07-20 Impact factor: 5.337
Authors: Victor D Martinez; Calum E MacAulay; Martial Guillaud; Wan L Lam; Lewei Zhang; Kitty K Corbett; Miriam P Rosin Journal: Oral Oncol Date: 2014-09-16 Impact factor: 5.337
Authors: O Gutierrez-Navarro; D U Campos-Delgado; E R Arce-Santana; Javier A Jo Journal: Comput Methods Programs Biomed Date: 2015-11-10 Impact factor: 5.428
Authors: Maria Menini; Emanuele De Giovanni; Francesco Bagnasco; Francesca Delucchi; Francesco Pera; Domenico Baldi; Paolo Pesce Journal: J Pers Med Date: 2021-02-04
Authors: Dong Li; Shu-Hong Hao; Yan Sun; Chun-Mei Hu; Zhi-Hua Ma; Zhi Ming Wang; Jie Liu; Hong Bo Liu; Ming Ye; Yu Fei Zhang; Dong Sheng Yang; Guang Shi Journal: Biomed Res Int Date: 2015-04-21 Impact factor: 3.411