Roshan S Prabhu1,2, Sheela Hanasoge1,2, Kelly R Magliocca3,2, William A Hall1,2, Susie A Chen4, Kristin A Higgins1,2, Nabil F Saba5,2, Mark El-Deiry6,2, William Grist6,2, J Trad Wadsworth6,2, Amy Y Chen6,2, Jonathan J Beitler1,2. 1. Department of Radiation Oncology, Emory University, Atlanta, Georgia. 2. Winship Cancer Institute, Emory University, Atlanta, Georgia. 3. Department of Pathology, Emory University, Atlanta, Georgia. 4. Department of Radiation Oncology, University of Texas Southwestern, Dallas, Texas. 5. Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia. 6. Department of Otolaryngology-Head and Neck Surgery, Emory University, Atlanta, Georgia.
Abstract
BACKGROUND: The purpose of this study was to determine if lymph node ratio is associated with locoregional recurrence for patients with oral cavity or laryngeal cancer treated with initial surgical management. METHODS: The study included 350 patients with oral cavity (73%) or laryngeal cancer (27%) who underwent initial surgery. All analyses were multivariable, adjusting for primary site, pathologic prognostic factors, and adjuvant therapy. RESULTS: Lymph node ratio was significantly associated with locoregional recurrence, in which each 1% increase in lymph node ratio had an adjusted hazard ratio (HR) for locoregional recurrence of 1.02 (95% confidence interval [CI], 1.002-1.042; p = .05). Lymph node ratio was also associated with OS, in which each 1% increase in lymph node ratio had an adjusted HR for death of 1.028 (95% CI, 1.012-1.045; p = .001). CONCLUSION: Adjusting for pathologic factors and adjuvant therapy, lymph node ratio was found to be an independent prognostic factor for locoregional recurrence and overall survival (OS). Patients with lymph node ratio ≥20% are at high risk of locoregional recurrence and death, and may be considered for adjuvant chemoradiation.
BACKGROUND: The purpose of this study was to determine if lymph node ratio is associated with locoregional recurrence for patients with oral cavity or laryngeal cancer treated with initial surgical management. METHODS: The study included 350 patients with oral cavity (73%) or laryngeal cancer (27%) who underwent initial surgery. All analyses were multivariable, adjusting for primary site, pathologic prognostic factors, and adjuvant therapy. RESULTS: Lymph node ratio was significantly associated with locoregional recurrence, in which each 1% increase in lymph node ratio had an adjusted hazard ratio (HR) for locoregional recurrence of 1.02 (95% confidence interval [CI], 1.002-1.042; p = .05). Lymph node ratio was also associated with OS, in which each 1% increase in lymph node ratio had an adjusted HR for death of 1.028 (95% CI, 1.012-1.045; p = .001). CONCLUSION: Adjusting for pathologic factors and adjuvant therapy, lymph node ratio was found to be an independent prognostic factor for locoregional recurrence and overall survival (OS). Patients with lymph node ratio ≥20% are at high risk of locoregional recurrence and death, and may be considered for adjuvant chemoradiation.
Authors: M de Ridder; C C M Marres; L E Smeele; M W M van den Brekel; M Hauptmann; A J M Balm; M L F van Velthuysen Journal: Virchows Arch Date: 2016-09-18 Impact factor: 4.064
Authors: Jan Oliver Voss; Lea Freund; Felix Neumann; Friedrich Mrosk; Kerstin Rubarth; Kilian Kreutzer; Christian Doll; Max Heiland; Steffen Koerdt Journal: Clin Oral Investig Date: 2022-07-27 Impact factor: 3.606
Authors: Sara Carvalho; Ralph T H Leijenaar; Esther G C Troost; Janna E van Timmeren; Cary Oberije; Wouter van Elmpt; Lioe-Fee de Geus-Oei; Johan Bussink; Philippe Lambin Journal: PLoS One Date: 2018-03-01 Impact factor: 3.240