Nathalie Auger1, Ashley I Naimi, Audrey Smargiassi, Ernest Lo, Tom Kosatsky. 1. From the aInstitut national de santé publique du Québec, Montreal, Quebec, Canada; bResearch Centre of the University of Montreal Hospital Centre, Montreal, Quebec, Canada; cDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; dDepartment of Environmental and Occupational Health, University of Montreal, Quebec, Canada; and eBritish Columbia Centre for Disease Control, Vancouver, British Columbia, Canada.
Abstract
BACKGROUND: The relationship between ambient temperature and risk of delivery is poorly understood. We examined the association between heat and risk of delivery among preterm and term pregnancies with the use of a time-to-event design to minimize bias from seasonal variation in conception rates. METHODS: We used data on 206,929 term and 12,390 preterm singleton live births for Montreal, Canada, from June through September, 1981-2010. The exposure variables were (1) maximum daily temperatures in the week preceding birth and (2) number of consecutive days with temperatures of 32°C or above during the preceding week. We estimated hazards of delivery among preterm (<37 gestational weeks), early-term (37-38 weeks), and full-term (≥39 weeks) pregnancies for both exposures in Cox regression models, adjusting for maternal characteristics. Sensitivity analyses were carried out adjusting for markers of air pollution. RESULTS: Maximum temperatures reached at least 32°C during the preceding week for 19,829 births (9.0%). Relative to a maximum of 20°C, the hazard of delivery within term was 4% higher for maximum temperatures of 32°C or higher, but no association was found for preterm delivery. Associations were stronger with early-term than with full-term delivery. Extreme heat episodes with 4 to 7 days of maximum temperature of at least 32°C were associated with a 27% greater hazard of delivery among early-term pregnancies relative to other days. CONCLUSION: High ambient temperature and extreme heat episodes may trigger earlier delivery among term births.
BACKGROUND: The relationship between ambient temperature and risk of delivery is poorly understood. We examined the association between heat and risk of delivery among preterm and term pregnancies with the use of a time-to-event design to minimize bias from seasonal variation in conception rates. METHODS: We used data on 206,929 term and 12,390 preterm singleton live births for Montreal, Canada, from June through September, 1981-2010. The exposure variables were (1) maximum daily temperatures in the week preceding birth and (2) number of consecutive days with temperatures of 32°C or above during the preceding week. We estimated hazards of delivery among preterm (<37 gestational weeks), early-term (37-38 weeks), and full-term (≥39 weeks) pregnancies for both exposures in Cox regression models, adjusting for maternal characteristics. Sensitivity analyses were carried out adjusting for markers of air pollution. RESULTS: Maximum temperatures reached at least 32°C during the preceding week for 19,829 births (9.0%). Relative to a maximum of 20°C, the hazard of delivery within term was 4% higher for maximum temperatures of 32°C or higher, but no association was found for preterm delivery. Associations were stronger with early-term than with full-term delivery. Extreme heat episodes with 4 to 7 days of maximum temperature of at least 32°C were associated with a 27% greater hazard of delivery among early-term pregnancies relative to other days. CONCLUSION: High ambient temperature and extreme heat episodes may trigger earlier delivery among term births.
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