OBJECTIVE: The aim of this study was to compare a cochlear implant electrode array loaded with dexamethasone (DXM) with a conventional passive electrode array for the preservation of residual hearing in gerbils. METHODS: Thirty Mongolian gerbils (Meriones unguiculatus) were implanted with an eluting electrode loaded with DXM (1 and 10%) on one side and a conventional passive electrode on the other side. Hearing thresholds were determined by tone bursts auditory brainstem responses at 4-6 weeks post-implantation and 1-year post-implantation for older gerbils. RESULTS: After 4-6 weeks post-implantation, residual hearing was statistically more preserved with electrode arrays loaded with DXM, regardless of concentration, for the frequencies 16 000 Hz (P = 0.0008), 4000 Hz (P = 0.0038), 1000 Hz (P = 0.0349), and 500 Hz (P = 0.0030). After 1 year, the difference in favor of the DXM+ electrode array was found statistically significant only for the frequency 16 000 Hz (P = 0.0103) but against it for the frequencies 1000 Hz (P = 0.0368) and 500 Hz (P = 0.0010). CONCLUSION: Electrode array with prolonged release of DXM improved short-term preservation of residual hearing after implantation for the frequencies 500, 1000, 4000, and 16 000 Hz in gerbils. The long-term results at 1 year confirmed these data for higher frequencies, but must be verified for the lower frequencies of 500 and 1000 Hz.
OBJECTIVE: The aim of this study was to compare a cochlear implant electrode array loaded with dexamethasone (DXM) with a conventional passive electrode array for the preservation of residual hearing in gerbils. METHODS: Thirty Mongolian gerbils (Meriones unguiculatus) were implanted with an eluting electrode loaded with DXM (1 and 10%) on one side and a conventional passive electrode on the other side. Hearing thresholds were determined by tone bursts auditory brainstem responses at 4-6 weeks post-implantation and 1-year post-implantation for older gerbils. RESULTS: After 4-6 weeks post-implantation, residual hearing was statistically more preserved with electrode arrays loaded with DXM, regardless of concentration, for the frequencies 16 000 Hz (P = 0.0008), 4000 Hz (P = 0.0038), 1000 Hz (P = 0.0349), and 500 Hz (P = 0.0030). After 1 year, the difference in favor of the DXM+ electrode array was found statistically significant only for the frequency 16 000 Hz (P = 0.0103) but against it for the frequencies 1000 Hz (P = 0.0368) and 500 Hz (P = 0.0010). CONCLUSION: Electrode array with prolonged release of DXM improved short-term preservation of residual hearing after implantation for the frequencies 500, 1000, 4000, and 16 000 Hz in gerbils. The long-term results at 1 year confirmed these data for higher frequencies, but must be verified for the lower frequencies of 500 and 1000 Hz.
Authors: Ya Liu; Claude Jolly; Susanne Braun; Thomas Stark; Elias Scherer; Stefan K Plontke; Jan Kiefer Journal: Eur Arch Otorhinolaryngol Date: 2015-08-29 Impact factor: 2.503
Authors: Cristina Maria Blebea; Laszlo Peter Ujvary; Violeta Necula; Maximilian George Dindelegan; Maria Perde-Schrepler; Mirela Cristina Stamate; Marcel Cosgarea; Alma Aurelia Maniu Journal: Medicina (Kaunas) Date: 2022-05-31 Impact factor: 2.948
Authors: Verena Scheper; Roland Hessler; Mareike Hütten; Maciej Wilk; Claude Jolly; Thomas Lenarz; Gerrit Paasche Journal: PLoS One Date: 2017-08-31 Impact factor: 3.240