OBJECTIVE: To compare the effects of oxytocin and dinoprostone used in labor induction on fetal blood gas parameters. MATERIAL AND METHODS: This prospective randomized trial involved 108 women who completed 37 gestational weeks and who required labor induction prior to normal vaginal birth. Labor was induced in 57 women with anintravenous low dose oxytocin regimen and in 51 with intravaginal dinoprostone (PGE2). Following childbirth, umbilical artery blood gas was analyzed, with pH, pCO2, pO2, HCO3 and base excess (BE) compared in the two groups. RESULTS:Mean age and obstetrical data (gravidity, parity, gestational weeks and birthweight) were similar in the two groups (p>0.05). All infants had 1 and 5 minute APGAR scores ≥7. Umbilical artery bloodpH was similar in the oxytocin and dinoprostone groups (7.31±0.07 vs. 7.31±0.05, p=0.780), as were the other blood gas parameters (pCO2, pO2, base excess and HCO3; p>0.05 each). CONCLUSION: Induction of labor with either oxytocin or dinoprostone in women with uncomplicated term pregnancies had no adverse effects on umbilical artery blood gas parameters.
RCT Entities:
OBJECTIVE: To compare the effects of oxytocin and dinoprostone used in labor induction on fetal blood gas parameters. MATERIAL AND METHODS: This prospective randomized trial involved 108 women who completed 37 gestational weeks and who required labor induction prior to normal vaginal birth. Labor was induced in 57 women with an intravenous low dose oxytocin regimen and in 51 with intravaginal dinoprostone (PGE2). Following childbirth, umbilical artery blood gas was analyzed, with pH, pCO2, pO2, HCO3 and base excess (BE) compared in the two groups. RESULTS: Mean age and obstetrical data (gravidity, parity, gestational weeks and birthweight) were similar in the two groups (p>0.05). All infants had 1 and 5 minute APGAR scores ≥7. Umbilical artery blood pH was similar in the oxytocin and dinoprostone groups (7.31±0.07 vs. 7.31±0.05, p=0.780), as were the other blood gas parameters (pCO2, pO2, base excess and HCO3; p>0.05 each). CONCLUSION: Induction of labor with either oxytocin or dinoprostone in women with uncomplicated term pregnancies had no adverse effects on umbilical artery blood gas parameters.
Entities:
Keywords:
Oxytocin; dinoproston; labor induction; pH; umbilical artery blood gas
Authors: Franklyn C Christensen; Mitra Tehranifar; Jose L Gonzalez; Clifford R Qualls; Valerie J Rappaport; William F Rayburn Journal: Am J Obstet Gynecol Date: 2002-01 Impact factor: 8.661
Authors: Ellen L Mozurkewich; Julie L Chilimigras; Deborah R Berman; Uma C Perni; Vivian C Romero; Valerie J King; Kristie L Keeton Journal: BMC Pregnancy Childbirth Date: 2011-10-27 Impact factor: 3.007