Ilker İnan Arıkan1, Aykut Barut1, Deniz Arıkan2, Müge Harma1, Mehmet İbrahim Harma1, Serpil Bozkurt3. 1. Department of Obstetrics and Gynecology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey. 2. Department of Gynecology and Obstetrics, Faculty of Medicine, Kahramanmaraş Sütcü İmam University, Kahramanmaraş, Turkey. 3. Department of Gynecology and Obstetrics, Faculty of Medicine, Maltepe University, İstanbul, Turkey.
Abstract
OBJECTIVE: In this study, we investigated whether serum androgen levels and endometrial thickness differed in obese and non-obese women. MATERIAL AND METHODS: Thirtytwo non-obese (BMI <30) and 48 obese (BMI ≥ 30) women were enrolled. Blood samples were analyzed for testosterone, free testosterone, androstenedione, DHEAS, and SHBG, and transvaginal ultrasonography was performed. RESULTS: Obese women had significantly higher free testosterone and endometrial thickness and significantly lower SHBG. Eight of 17 women with endometrial thickness >5 mm had significant pathology. CONCLUSION: These results suggest that obesity may be a risk factor for endometrial carcinoma and other pathologies in post-menopausal women through an action on androgen concentrations.
OBJECTIVE: In this study, we investigated whether serum androgen levels and endometrial thickness differed in obese and non-obesewomen. MATERIAL AND METHODS: Thirtytwo non-obese (BMI <30) and 48 obese (BMI ≥ 30) women were enrolled. Blood samples were analyzed for testosterone, free testosterone, androstenedione, DHEAS, and SHBG, and transvaginal ultrasonography was performed. RESULTS:Obesewomen had significantly higher free testosterone and endometrial thickness and significantly lower SHBG. Eight of 17 women with endometrial thickness >5 mm had significant pathology. CONCLUSION: These results suggest that obesity may be a risk factor for endometrial carcinoma and other pathologies in post-menopausal women through an action on androgen concentrations.
Authors: Annekatrin Lukanova; Eva Lundin; Andrea Micheli; Alan Arslan; Pietro Ferrari; Sabina Rinaldi; Vittorio Krogh; Per Lenner; Roy E Shore; Carine Biessy; Paola Muti; Elio Riboli; Karen L Koenig; Mortimer Levitz; Pär Stattin; Franco Berrino; Göran Hallmans; Rudolf Kaaks; Paolo Toniolo; Anne Zeleniuch-Jacquotte Journal: Int J Cancer Date: 2004-01-20 Impact factor: 7.396