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Literature DB >> 2459096

Saframycin Mx1, a new natural saframycin isolated from a myxobacterium.

H Irschik¹, W Trowitzsch-Kienast, K Gerth, G Höfle, H Reichenbach.

Abstract

A new natural saframycin was discovered in the culture broth of the myxobacterium, Myxococcus xanthus strain Mx x48. The fermentation and isolation of the antibiotic are described. The name, saframycin Mx1, is proposed. The compound appears to interact with cellular DNA.

Entities: Chemical Species

Mesh：

Substances：

Year: 1988 PMID： 2459096 DOI： 10.7164/antibiotics.41.993

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

13 in total

1. Molecular cloning, sequence analysis, and characterization of a penicillin-resistant DD-carboxypeptidase of Myxococcus xanthus.

Authors: Y Kimura; Y Takashima; Y Tokumasu; M Sato
Journal: J Bacteriol Date: 1999-08 Impact factor: 3.490

2. Improvement of glidobactin A production by Polyangium brachysporum.

Authors: J A Titus; C A Roundy
Journal: J Ind Microbiol Date: 1990-11

Review 3. Analysis of myxobacterial secondary metabolism goes molecular.

Authors: Helge B Bode; Rolf Müller
Journal: J Ind Microbiol Biotechnol Date: 2006-02-21 Impact factor: 3.346

Review 4. Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics.

Authors: V H Le; M Inai; R M Williams; T Kan
Journal: Nat Prod Rep Date: 2015-02 Impact factor: 13.423

5. Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743.

Authors: Christopher M Rath; Benjamin Janto; Josh Earl; Azad Ahmed; Fen Z Hu; Luisa Hiller; Meg Dahlgren; Rachael Kreft; Fengan Yu; Jeremy J Wolff; Hye Kyong Kweon; Michael A Christiansen; Kristina Håkansson; Robert M Williams; Garth D Ehrlich; David H Sherman
Journal: ACS Chem Biol Date: 2011-09-20 Impact factor: 5.100

Review 6. Scrutinizing the scaffolds of marine biosynthetics from different source organisms: Gram-negative cultured bacterial products enter center stage.

Authors: Patrick C Still; Tyler A Johnson; Christine M Theodore; Steven T Loveridge; Phillip Crews
Journal: J Nat Prod Date: 2014-02-26 Impact factor: 4.050

Saframycin Mx1, a new natural saframycin isolated from a myxobacterium.

1. Molecular cloning, sequence analysis, and characterization of a penicillin-resistant DD-carboxypeptidase of Myxococcus xanthus.

2. Improvement of glidobactin A production by Polyangium brachysporum.

Review 3. Analysis of myxobacterial secondary metabolism goes molecular.

Review 4. Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics.

5. Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743.

Review 6. Scrutinizing the scaffolds of marine biosynthetics from different source organisms: Gram-negative cultured bacterial products enter center stage.

7. Discovering the hidden secondary metabolome of Myxococcus xanthus: a study of intraspecific diversity.

8. Characterization of SafC, a catechol 4-O-methyltransferase involved in saframycin biosynthesis.

Review 9. Predominately Uncultured Microbes as Sources of Bioactive Agents.

Review 10. Antimicrobial peptides from marine proteobacteria.