V Crincoli1, M Di Comite2, M B Di Bisceglie1, M Petruzzi1, L Fatone1, C De Biase1, S Tecco3, F Festa3. 1. Interdisciplinary Department of Medicine, University of Bari. 2. Department of Basic Medical Sciences - NOS, University of Bari. 3. Department of Oral Medical Sciences and Biotechnologies, University of Chieti, Italy.
Abstract
OBJECTIVE: To compare the effectiveness of two different routes of antibiotic administration in preventing septic complications in patients undergoing third molar extraction. MATERIALS AND METHODS:Twenty-four healthy patients requiring bilateral surgical removal of impacted mandibular third molars were successfully enrolled for this study. Depth of impaction, angulation, and relationship of the lower third molars with the mandibular branch had to be overlapping on both sides. A split-mouth design was chosen, so each patient underwent both the first and second surgeries, having for each extraction a different antibiotic route of administration. The second extraction was carried out 1 month later. To compare the effects of the two routes of antibiotic administration, inflammatory parameters, such as edema, trismus, pain, fever, dysphagia and lymphadenopathy were evaluated 2 and 7 days after surgery. Side effects of each therapy were evaluated 48 h after surgery. RESULTS: Oral and intramuscular antibiotic therapies overlap in preventing post-operative complications in dental surgery (p>0.05), even if the oral intake, seems to promote the onset of significant gastrointestinal disorders (p=0.003). CONCLUSIONS: This study could help dentists in their ordinary practice to choose the right route of antibiotic administration in the third molar surgery. At the same effectiveness, the higher cost and the minor compliance of the patient seem not to justify a routine antibiotic intramuscular therapy, reserving it for patients with gastrointestinal disorders.
RCT Entities:
OBJECTIVE: To compare the effectiveness of two different routes of antibiotic administration in preventing septic complications in patients undergoing third molar extraction. MATERIALS AND METHODS: Twenty-four healthy patients requiring bilateral surgical removal of impacted mandibular third molars were successfully enrolled for this study. Depth of impaction, angulation, and relationship of the lower third molars with the mandibular branch had to be overlapping on both sides. A split-mouth design was chosen, so each patient underwent both the first and second surgeries, having for each extraction a different antibiotic route of administration. The second extraction was carried out 1 month later. To compare the effects of the two routes of antibiotic administration, inflammatory parameters, such as edema, trismus, pain, fever, dysphagia and lymphadenopathy were evaluated 2 and 7 days after surgery. Side effects of each therapy were evaluated 48 h after surgery. RESULTS: Oral and intramuscular antibiotic therapies overlap in preventing post-operative complications in dental surgery (p>0.05), even if the oral intake, seems to promote the onset of significant gastrointestinal disorders (p=0.003). CONCLUSIONS: This study could help dentists in their ordinary practice to choose the right route of antibiotic administration in the third molar surgery. At the same effectiveness, the higher cost and the minor compliance of the patient seem not to justify a routine antibiotic intramuscular therapy, reserving it for patients with gastrointestinal disorders.
Authors: Vito Crincoli; Angela Pia Cazzolla; Mariasevera Di Comite; Lorenzo Lo Muzio; Domenico Ciavarella; Mario Dioguardi; Maria Eleonora Bizzoca; Giuseppe Palmieri; Antonietta Fontana; Arcangela Giustino; Michele Di Cosola; Brescia Vincenzo; Roberto Lovero; Francesca Di Serio Journal: Nutrients Date: 2021-06-04 Impact factor: 5.717
Authors: Gabriele Cervino; Marco Cicciù; Antonio Biondi; Salvatore Bocchieri; Alan Scott Herford; Luigi Laino; Luca Fiorillo Journal: Antibiotics (Basel) Date: 2019-05-02