Literature DB >> 24589860

Toward the ideal synthesis and molecular function through synthesis-informed design.

Paul A Wender1.   

Abstract

This Highlight describes factors that contribute to an ideal synthesis, including economies (step, time, atom, solvent, energy) and orientations (target, diversity, safety, function), and the role of synthesis-informed design directed at function in advancing synthesis and its impact on science.

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Year:  2014        PMID： 24589860     DOI： 10.1039/c4np00013g

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  32 in total

1.  β-Carbolinone Analogues from the Ugi Silver Mine.

Authors:  Rudrakshula Madhavachary; Naganaboina Naveen; Yuanze Wang; Qian Wang; Markella Konstantinidou; Alexander Dömling
Journal:  European J Org Chem       Date:  2018-04-17

2.  Bridging the gap between natural product synthesis and drug discovery.

Authors:  Nathanyal J Truax; Daniel Romo
Journal:  Nat Prod Rep       Date:  2020-10-26       Impact factor: 13.423

3.  Sequential C-H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD-1 Inhibitor.

Authors:  Xudong Wei; Bo Qu; Xingzhong Zeng; Jolaine Savoie; Keith R Fandrick; Jean-Nicolas Desrosiers; Sergei Tcyrulnikov; Maurice A Marsini; Frederic G Buono; Zhibin Li; Bing-Shiou Yang; Wenjun Tang; Nizar Haddad; Osvaldo Gutierrez; Jun Wang; Heewon Lee; Shengli Ma; Scot Campbell; Jon C Lorenz; Matthias Eckhardt; Frank Himmelsbach; Stefan Peters; Nitinchandra D Patel; Zhulin Tan; Nathan K Yee; Jinhua J Song; Frank Roschangar; Marisa C Kozlowski; Chris H Senanayake
Journal:  J Am Chem Soc       Date:  2016-11-17       Impact factor: 15.419

4.  A Highly Chemo-, Regio-, and Stereoselective Metallacycle-Mediated Annulation Between a Conjugated Enyne and an Ene-Diyne.

Authors:  Zachary A Shalit; Glenn C Micalizio
Journal:  ARKIVOC       Date:  2018-03-28       Impact factor: 1.140

5.  Catalytic Efficiency Is a Function of How Rhodium(I) (5 + 2) Catalysts Accommodate a Conserved Substrate Transition State Geometry: Induced Fit Model for Explaining Transition Metal Catalysis.

Authors:  Thomas J L Mustard; Paul A Wender; Paul Ha-Yeon Cheong
Journal:  ACS Catal       Date:  2015-03-06       Impact factor: 13.084

6.  Ynol Ethers as Ketene Equivalents in Rhodium-Catalyzed Intermolecular [5 + 2] Cycloaddition Reactions.

Authors:  Paul A Wender; Christian Ebner; Brandon D Fennell; Fuyuhiko Inagaki; Birte Schröder
Journal:  Org Lett       Date:  2017-11-03       Impact factor: 6.005

7.  A Complementary Process to Pauson-Khand-Type Annulation Reactions for the Construction of Fully Substituted Cyclopentenones.

Authors:  Adam B Millham; Matthew J Kier; Robert M Leon; Rajdip Karmakar; Zachary D Stempel; Glenn C Micalizio
Journal:  Org Lett       Date:  2019-01-07       Impact factor: 6.005

8.  A Pot-Economical Approach to the Total Synthesis of Sch-725674.

Authors:  Mahipal Bodugam; Salim Javed; Arghya Ganguly; Jessica Torres; Paul R Hanson
Journal:  Org Lett       Date:  2016-01-13       Impact factor: 6.005

9.  Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence.

Authors:  M Alejandro Valdes-Pena; Nicholas P Massaro; You-Chen Lin; Joshua G Pierce
Journal:  Acc Chem Res       Date:  2021-03-18       Impact factor: 22.384

10.  Pot and time economies in the total synthesis of Corey lactone.

Authors:  Nariyoshi Umekubo; Yurina Suga; Yujiro Hayashi
Journal:  Chem Sci       Date:  2019-12-23       Impact factor: 9.825
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