Literature DB >> 31440115

β-Carbolinone Analogues from the Ugi Silver Mine.

Rudrakshula Madhavachary1, Naganaboina Naveen1, Yuanze Wang1, Qian Wang1, Markella Konstantinidou1, Alexander Dömling1.   

Abstract

Here we describe a facile, tandem synthetic route for β-carbolinones, a class of natural products of high biological significance. Commercially available building blocks yield highly diverse analogues in just two simple steps.

Entities:  

Keywords:  B-Carboline; Isocyanide; Multicomponent reactions; Propargyl; Ugi-reaction

Year:  2018        PMID： 31440115      PMCID： PMC6706090          DOI： 10.1002/ejoc.201800557

Source DB:  PubMed          Journal:  European J Org Chem        ISSN： 1099-0690


  23 in total

1.  Maximizing synthetic efficiency: multi-component transformations lead the way

Authors: 
Journal:  Chemistry       Date:  2000-09-15       Impact factor: 5.236

2.  Multicomponent Reactions with Isocyanides.

Authors: 
Journal:  Angew Chem Int Ed Engl       Date:  2000-09-15       Impact factor: 15.336

3.  Aiming for the ideal synthesis.

Authors:  Tanja Gaich; Phil S Baran
Journal:  J Org Chem       Date:  2010-07-16       Impact factor: 4.354

4.  Sequential one-pot combination of multi-component and multi-catalysis cascade reactions: an emerging technology in organic synthesis.

Authors:  Dhevalapally B Ramachary; Sangeeta Jain
Journal:  Org Biomol Chem       Date:  2010-12-01       Impact factor: 3.876

Review 5.  Recent developments in isocyanide based multicomponent reactions in applied chemistry.

Authors:  Alexander Dömling
Journal:  Chem Rev       Date:  2006-01       Impact factor: 60.622

6.  Synthesis of beta- and gamma-carbolinones via Pd-catalyzed direct dehydrogenative annulation (DDA) of indole-carboxamides with alkynes using air as the oxidant.

Authors:  Zhuangzhi Shi; Yuxin Cui; Ning Jiao
Journal:  Org Lett       Date:  2010-07-02       Impact factor: 6.005

Review 7.  SL651498, a GABAA receptor agonist with subtype-selective efficacy, as a potential treatment for generalized anxiety disorder and muscle spasms.

Authors:  Guy Griebel; Ghislaine Perrault; Jacques Simiand; Caroline Cohen; Patrick Granger; Henri Depoortere; Dominique Françon; Patrick Avenet; Hans Schoemaker; Yannick Evanno; Mireille Sevrin; Pascal George; Bernard Scatton
Journal:  CNS Drug Rev       Date:  2003

8.  Synthesis, modeling, and RET protein kinase inhibitory activity of 3- and 4-substituted beta-carbolin-1-ones.

Authors:  Raffaella Cincinelli; Giuliana Cassinelli; Sabrina Dallavalle; Cinzia Lanzi; Lucio Merlini; Maurizio Botta; Tiziano Tuccinardi; Adriano Martinelli; Sergio Penco; Franco Zunino
Journal:  J Med Chem       Date:  2008-12-25       Impact factor: 7.446

9.  Gold-catalyzed cycloisomerization of N-Propargylindole-2-carboxamides: application toward the synthesis of lavendamycin analogues.

Authors:  Dylan B England; Albert Padwa
Journal:  Org Lett       Date:  2008-07-16       Impact factor: 6.005

10.  A facile synthesis of 3-substituted 9H-pyrido[3,4-b]indol-1(2H)-one derivatives from 3-substituted beta-carbolines.

Authors:  Guowu Lin; Yue Wang; Qingfa Zhou; Weifang Tang; Jian Wang; Tao Lu
Journal:  Molecules       Date:  2010-08-17       Impact factor: 4.411
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  1 in total

1.  Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction.

Authors:  Maryna V Murlykina; Oleksandr V Kolomiets; Maryna M Kornet; Yana I Sakhno; Sergey M Desenko; Victoriya V Dyakonenko; Svetlana V Shishkina; Oleksandr A Brazhko; Vladimir I Musatov; Alexander V Tsygankov; Erik V Van der Eycken; Valentyn A Chebanov
Journal:  Beilstein J Org Chem       Date:  2019-06-12       Impact factor: 2.883
  1 in total

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