Yong Kyun Kim1, Su-Hyun Kim1, Hyung Wook Kim1, Young Ok Kim1, Dong Chan Jin1, Ho Chul Song1, Euy Jin Choi1, Yong-Lim Kim1, Yon-Su Kim1, Shin-Wook Kang1, Nam-Ho Kim1, Chul Woo Yang1. 1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea; Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea; Department of Internal Medicine, School of Medicine, Kyungpook National University, Korea; Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea; Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea; Department of Internal Medicine, Chonnam National University Medical School, Korea.
Abstract
BACKGROUND: Previous studies have demonstrated that increased body mass index (BMI) is associated with decreased mortality in hemodialysis (HD) patients. However, the association between BMI and survival has not been well established in patients undergoing peritoneal dialysis (PD). The aim of the study was to determine the association between BMI and mortality in the PD population using the Clinical Research Center (CRC) registry for end-stage renal disease (ESRD) cohort in Korea. METHODS: Prevalent patients with PD were selected from the CRC registry for ESRD, a prospective cohort study on dialysis patients in Korea. Patients were categorized into four groups by quartiles of BMI. Cox regression analysis was used to calculate the adjusted hazard ratio (HR) of mortality with a BMI of quartile 2 (21.4 - 23.5 kg/m(2)) as the reference. RESULTS: A total of 900 prevalent patients undergoing PD were included. The median follow-up period was 24 months. The multivariate Cox proportional hazard model showed that the lowest quartile of BMI was associated with higher mortality (HR 3.00, 95% confidence interval (CI), 1.26 - 7.15). However, the higher quartiles of BMI were not associated with mortality compared with the reference category of BMI quartile 2 (Quartile 3: HR 1.11, 95% CI, 0.43 - 2.85, Quartile 4: HR 1.64, 95% CI, 0.66 - 4.06) after adjustment for clinical variables. CONCLUSIONS: Lower BMI was a significant risk factor for death, but increased BMI was not associated with mortality in Korean PD patients.
BACKGROUND: Previous studies have demonstrated that increased body mass index (BMI) is associated with decreased mortality in hemodialysis (HD) patients. However, the association between BMI and survival has not been well established in patients undergoing peritoneal dialysis (PD). The aim of the study was to determine the association between BMI and mortality in the PD population using the Clinical Research Center (CRC) registry for end-stage renal disease (ESRD) cohort in Korea. METHODS: Prevalent patients with PD were selected from the CRC registry for ESRD, a prospective cohort study on dialysis patients in Korea. Patients were categorized into four groups by quartiles of BMI. Cox regression analysis was used to calculate the adjusted hazard ratio (HR) of mortality with a BMI of quartile 2 (21.4 - 23.5 kg/m(2)) as the reference. RESULTS: A total of 900 prevalent patients undergoing PD were included. The median follow-up period was 24 months. The multivariate Cox proportional hazard model showed that the lowest quartile of BMI was associated with higher mortality (HR 3.00, 95% confidence interval (CI), 1.26 - 7.15). However, the higher quartiles of BMI were not associated with mortality compared with the reference category of BMI quartile 2 (Quartile 3: HR 1.11, 95% CI, 0.43 - 2.85, Quartile 4: HR 1.64, 95% CI, 0.66 - 4.06) after adjustment for clinical variables. CONCLUSIONS: Lower BMI was a significant risk factor for death, but increased BMI was not associated with mortality in Korean PDpatients.
Authors: D W Johnson; K A Herzig; D M Purdie; W Chang; A M Brown; R J Rigby; S B Campbell; D L Nicol; C M Hawley Journal: Perit Dial Int Date: 2000 Nov-Dec Impact factor: 1.756
Authors: Ellen K Hoogeveen; Nynke Halbesma; Kenneth J Rothman; Theo Stijnen; Sandra van Dijk; Friedo W Dekker; Elisabeth W Boeschoten; Renée de Mutsert Journal: Clin J Am Soc Nephrol Date: 2012-01-05 Impact factor: 8.237
Authors: Chi Pang Wen; Ting Yuan David Cheng; Shan Pou Tsai; Hui Ting Chan; Hui Ling Hsu; Chih Cheng Hsu; Michael P Eriksen Journal: Public Health Nutr Date: 2008-06-12 Impact factor: 4.022
Authors: Zhi Xu; Glen H Murata; Robert H Glew; Yijuan Sun; Darlene Vigil; Karen S Servilla; Antonios H Tzamaloukas Journal: World J Nephrol Date: 2017-05-06