DaoQi Wu1, HaiPing Yang1, Juan Luo2, GaoFu Zhang1, ShaoJun Li1, Mo Wang1, XueHei Tang1, Zhitie Wang1, ZhenE Xu1, Qiu Li3. 1. Department of Nephroimmunology, Key Laboratory of the Ministry of Education, Children's Hospital of Chongqing Medical University, Chongqing, China. 2. Chongqing Ninth People's Hospital, Chongqing, China. 3. Department of Nephroimmunology, Key Laboratory of the Ministry of Education, Children's Hospital of Chongqing Medical University, Chongqing, China. Electronic address: liqiu809@126.com.
Abstract
BACKGROUND: The reference value for the urine albumin/creatinine ratio (ACR) varies between races and has not been previously validated in children. We assessed the ACR reference values and the factors that affect them in a population of healthy Chinese children. METHODS: A total of 1986 healthy children (1078 males, 908 females) aged 6-19 y were enrolled. The 95th percentile of ACR was used as the normal upper limit. The associations between ACR and gender, age, body mass index (BMI), systolic blood pressure (SBP), preterm birth, intake of fruits, smoking, and geographical area were examined. RESULTS: The normal upper limit of ACR was 14.7 mg/g for male children and 19.8 mg/g for female children. The ACR value for girls was significantly higher than that for boys (P<0.001). ACR was inversely correlated with age (P<0.001) and positively correlated with BMI, SBP, and smoking (all P<0.01). CONCLUSIONS: The ACR reference value for healthy children in southwest China is approximately the same as the value for adults, but lower than that for the Western population. Age, SBP, BMI, and smoking in children influence ACR.
BACKGROUND: The reference value for the urine albumin/creatinine ratio (ACR) varies between races and has not been previously validated in children. We assessed the ACR reference values and the factors that affect them in a population of healthy Chinese children. METHODS: A total of 1986 healthy children (1078 males, 908 females) aged 6-19 y were enrolled. The 95th percentile of ACR was used as the normal upper limit. The associations between ACR and gender, age, body mass index (BMI), systolic blood pressure (SBP), preterm birth, intake of fruits, smoking, and geographical area were examined. RESULTS: The normal upper limit of ACR was 14.7 mg/g for male children and 19.8 mg/g for female children. The ACR value for girls was significantly higher than that for boys (P<0.001). ACR was inversely correlated with age (P<0.001) and positively correlated with BMI, SBP, and smoking (all P<0.01). CONCLUSIONS: The ACR reference value for healthy children in southwest China is approximately the same as the value for adults, but lower than that for the Western population. Age, SBP, BMI, and smoking in children influence ACR.
Authors: Erick Sierra-Diaz; Alfredo de Jesus Celis-de la Rosa; Felipe Lozano-Kasten; Alejandro Bravo-Cuellar; Mariana Garcia-Gutierrez; Hernandez-Flores Georgina Journal: Int J Environ Res Public Health Date: 2017-10-16 Impact factor: 3.390
Authors: Wei Wang; Cong Du; Laixiang Lin; Wen Chen; Long Tan; Jun Shen; Elizabeth N Pearce; Yixin Zhang; Min Gao; Jianchao Bian; Xiaoming Wang; Wanqi Zhang Journal: PLoS One Date: 2018-05-23 Impact factor: 3.240
Authors: Felipe Lozano-Kasten; Erick Sierra-Diaz; Alfredo de Jesus Celis-de la Rosa; María Margarita Soto Gutiérrez; Alejandro Aarón Peregrina Lucano Journal: Int J Environ Res Public Health Date: 2017-12-14 Impact factor: 3.390