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Literature DB >> 24581918

Evaluation of nicotine and cotinine analogs as potential neuroprotective agents for Alzheimer's disease.

Jie Gao¹, Bao-Ling Adam¹, Alvin V Terry².

Abstract

The currently available therapies for Alzheimer's disease (AD) and related forms of dementia are limited by modest efficacy, adverse side effects, and the fact that they do not prevent the relentless progression of the illness. The purpose of the studies described here was to investigate the neuroprotective effects of the nicotine metabolite cotinine as well as a small series of cotinine and nicotine analogs (including stereoisomers) and to compare their effects to the four clinically prescribed AD therapies.

Entities: CellLine Chemical Disease Gene Species

Keywords: Amyloid; Dementia; Disease modifying; Excitotoxicity; Glutamate; Multi-target-directed ligands; Multifunctional compounds; Neurodegeneration; Neuroprotection; Nicotinic

Mesh：

Substances：

Year: 2014 PMID： 24581918 PMCID： PMC4027973 DOI： 10.1016/j.bmcl.2014.02.008

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

32 in total

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Authors: D K Hatsukami; M Grillo; P R Pentel; C Oncken; R Bliss
Journal: Pharmacol Biochem Behav Date: 1997-08 Impact factor: 3.533

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Authors: Florence Serres; Stephen L Carney
Journal: Brain Res Date: 2006-06-21 Impact factor: 3.252

Review 3. Multifunctional receptor-directed drugs for disorders of the central nervous system.

Authors: Jerry J Buccafusco
Journal: Neurotherapeutics Date: 2009-01 Impact factor: 7.620

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Authors: Wenfeng Yu; Naguib Mechawar; Slavica Krantic; Rémi Quirion
Journal: J Neurochem Date: 2011-10-03 Impact factor: 5.372

Review 5. Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease.

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Journal: Med Res Rev Date: 2011-07-26 Impact factor: 12.944

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Authors: Marina R Picciotto; Michele Zoli
Journal: Front Biosci Date: 2008-01-01

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Authors: D J Anderson; S P Arneric
Journal: Eur J Pharmacol Date: 1994-03-03 Impact factor: 4.432

9. Cigarette smoke, nicotine and cotinine protect against 6-hydroxydopamine-induced toxicity in SH-SY5Y cells.

Authors: Karen Riveles; Luping Z Huang; Maryka Quik
Journal: Neurotoxicology Date: 2008-02-14 Impact factor: 4.294

Review 10. Desensitization of nicotinic acetylcholine receptors as a strategy for drug development.

Authors: Jerry J Buccafusco; J Warren Beach; Alvin V Terry
Journal: J Pharmacol Exp Ther Date: 2008-11-20 Impact factor: 4.030

20 in total

1. Pharmacokinetics of cotinine in rats: a potential therapeutic agent for disorders of cognitive function.

Authors: Pei Li; Wayne D Beck; Patrick M Callahan; Alvin V Terry; Michael G Bartlett
Journal: Pharmacol Rep Date: 2014-12-16 Impact factor: 3.024

2. Cotinine administration improves impaired cognition in the mouse model of Fragile X syndrome.

Authors: Marta Pardo; Eleonore Beurel; Richard S Jope
Journal: Eur J Neurosci Date: 2016-11-12 Impact factor: 3.386

Review 3. A decade of e-cigarettes: Limited research & unresolved safety concerns.

Authors: Mohammad Abul Kaisar; Shikha Prasad; Tylor Liles; Luca Cucullo
Journal: Toxicology Date: 2016-07-28 Impact factor: 4.221

Review 4. The Black Book of Psychotropic Dosing and Monitoring.

Authors: Alan F Schatzberg; DeBattista Charles
Journal: Psychopharmacol Bull Date: 2018-01-15

5. Diisopropylfluorophosphate Impairs the Transport of Membrane-Bound Organelles in Rat Cortical Axons.

Authors: Jie Gao; Sean X Naughton; Heike Wulff; Vikrant Singh; Wayne D Beck; Jordi Magrane; Bobby Thomas; Navneet Ammal Kaidery; Caterina M Hernandez; Alvin V Terry
Journal: J Pharmacol Exp Ther Date: 2015-12-30 Impact factor: 4.030

6. Chlorpyrifos and chlorpyrifos oxon impair the transport of membrane bound organelles in rat cortical axons.

Authors: Jie Gao; Sean X Naughton; Wayne D Beck; Caterina M Hernandez; Guangyu Wu; Zhe Wei; Xiangkun Yang; Michael G Bartlett; Alvin V Terry
Journal: Neurotoxicology Date: 2017-06-12 Impact factor: 4.294

Review 7. Nicotinic ligands as multifunctional agents for the treatment of neuropsychiatric disorders.

Authors: Alvin V Terry; Patrick M Callahan; Caterina M Hernandez
Journal: Biochem Pharmacol Date: 2015-07-29 Impact factor: 5.858

Review 8. Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder.

Authors: Cristhian Mendoza; George E Barreto; Alexandre Iarkov; Vadim V Tarasov; Gjumrakch Aliev; Valentina Echeverria
Journal: Mol Neurobiol Date: 2018-01-15 Impact factor: 5.590

9. Nicotinic receptor activation contrasts pathophysiological bursting and neurodegeneration evoked by glutamate uptake block on rat hypoglossal motoneurons.

Authors: Silvia Corsini; Maria Tortora; Andrea Nistri
Journal: J Physiol Date: 2016-08-03 Impact factor: 5.182

Review 10. New Insights into the Mechanisms of Action of Cotinine and its Distinctive Effects from Nicotine.

Authors: J Alex Grizzell; Valentina Echeverria
Journal: Neurochem Res Date: 2014-06-27 Impact factor: 3.996