Literature DB >> 29335846

Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder.

Cristhian Mendoza1, George E Barreto2,3, Alexandre Iarkov1, Vadim V Tarasov4, Gjumrakch Aliev5,6,7, Valentina Echeverria8,9.   

Abstract

Post-traumatic stress disorder (PTSD) is a mental disorder that may develop after exposure to exceptionally threatening or unescapable horrifying events. Actual therapies fail to alleviate the emotional suffering and cognitive impairment associated with this disorder, mostly because they are ineffective in treating the failure to extinguish trauma memories in a great percentage of those affected. In this review, current behavioral, cellular, and molecular evidence supporting the use of cotinine for treating PTSD are reviewed. The role of the positive modulation by cotinine of the nicotinic acetylcholine receptors (nAChRs) and their downstream effectors, the protection of astroglia, and the inhibition of microglia in the PTSD brain are also discussed.

Entities:  

Keywords:  Cotinine; Extinction; Fear; Inflammation; Nicotinic receptor; Post-traumatic stress disorder

Mesh：

Substances：

Year:  2018        PMID： 29335846     DOI： 10.1007/s12035-018-0869-3

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  177 in total

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Authors:  Z Z Chong; F Li; K Maiese
Journal:  Histol Histopathol       Date:  2005-01       Impact factor: 2.303

Review 2.  How can we increase physical activity and exercise among youth experiencing first-episode psychosis? A systematic review of intervention variables.

Authors:  Simon Rosenbaum; Oscar Lederman; Brendon Stubbs; Davy Vancampfort; Robert Stanton; Philip B Ward
Journal:  Early Interv Psychiatry       Date:  2015-03-23       Impact factor: 2.732

3.  Cotinine enhances the extinction of contextual fear memory and reduces anxiety after fear conditioning.

Authors:  Ross Zeitlin; Sagar Patel; Rosalynn Solomon; John Tran; Edwin J Weeber; Valentina Echeverria
Journal:  Behav Brain Res       Date:  2011-11-28       Impact factor: 3.332

4.  Cotinine exposure increases Fallopian tube PROKR1 expression via nicotinic AChRalpha-7: a potential mechanism explaining the link between smoking and tubal ectopic pregnancy.

Authors:  Julie L V Shaw; Elizabeth Oliver; Kai-Fai Lee; Gary Entrican; Henry N Jabbour; Hilary O D Critchley; Andrew W Horne
Journal:  Am J Pathol       Date:  2010-09-23       Impact factor: 4.307

5.  Neurons in medial prefrontal cortex signal memory for fear extinction.

Authors:  Mohammed R Milad; Gregory J Quirk
Journal:  Nature       Date:  2002-11-07       Impact factor: 49.962

6.  Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder.

Authors:  Zhen Wang; Thomas C Neylan; Susanne G Mueller; Maryann Lenoci; Diana Truran; Charles R Marmar; Michael W Weiner; Norbert Schuff
Journal:  Arch Gen Psychiatry       Date:  2010-03

7.  Recall of emotional states in posttraumatic stress disorder: an fMRI investigation.

Authors:  Ruth A Lanius; Peter C Williamson; James Hopper; Maria Densmore; Kristine Boksman; Madhulika A Gupta; Robert W J Neufeld; Joseph S Gati; Ravi S Menon
Journal:  Biol Psychiatry       Date:  2003-02-01       Impact factor: 13.382

Review 8.  Neuroimaging findings in post-traumatic stress disorder. Systematic review.

Authors:  Alastair M Hull
Journal:  Br J Psychiatry       Date:  2002-08       Impact factor: 9.319

9.  Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium.

Authors:  Sevag A Kaladchibachi; Brad Doble; Norman Anthopoulos; James R Woodgett; Armen S Manoukian
Journal:  J Circadian Rhythms       Date:  2007-02-12

10.  Influence of post-traumatic stress disorder on neuroinflammation and cell proliferation in a rat model of traumatic brain injury.

Authors:  Sandra A Acosta; David M Diamond; Steven Wolfe; Naoki Tajiri; Kazutaka Shinozuka; Hiroto Ishikawa; Diana G Hernandez; Paul R Sanberg; Yuji Kaneko; Cesar V Borlongan
Journal:  PLoS One       Date:  2013-12-09       Impact factor: 3.240
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  5 in total

Review 1.  The Walking Wounded: Emerging Treatments for PTSD.

Authors:  Durga Bestha; Layla Soliman; Kelly Blankenship; James Rachal
Journal:  Curr Psychiatry Rep       Date:  2018-09-14       Impact factor: 5.285

2.  Nicotine and electronic cigarette (E-Cig) exposure decreases brain glucose utilization in ischemic stroke.

Authors:  Ali E Sifat; Bhuvaneshwar Vaidya; Mohammad A Kaisar; Luca Cucullo; Thomas J Abbruscato
Journal:  J Neurochem       Date:  2018-10-18       Impact factor: 5.372

3.  Cotinine Enhances Fear Extinction and Astrocyte Survival by Mechanisms Involving the Nicotinic Acetylcholine Receptors Signaling.

Authors:  Patricia Oliveros-Matus; Nelson Perez-Urrutia; Nathalie Alvarez-Ricartes; Florencia Echeverria; George E Barreto; James Elliott; Alexandre Iarkov; Valentina Echeverria
Journal:  Front Pharmacol       Date:  2020-04-02       Impact factor: 5.810

Review 4.  Cotinine: Pharmacologically Active Metabolite of Nicotine and Neural Mechanisms for Its Actions.

Authors:  Xiaoying Tan; Kent Vrana; Zheng-Ming Ding
Journal:  Front Behav Neurosci       Date:  2021-10-21       Impact factor: 3.617

Review 5.  Neurophysiology and Psychopathology Underlying PTSD and Recent Insights into the PTSD Therapies-A Comprehensive Review.

Authors:  Gjumrakch Aliev; Narasimha M Beeraka; Vladimir N Nikolenko; Andrey A Svistunov; Tatyana Rozhnova; Svetlana Kostyuk; Igor Cherkesov; Liliya V Gavryushova; Andrey A Chekhonatsky; Liudmila M Mikhaleva; Siva G Somasundaram; Marco F Avila-Rodriguez; Cecil E Kirkland
Journal:  J Clin Med       Date:  2020-09-12       Impact factor: 4.241
  5 in total

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