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Literature DB >> 2458043

Bleomycin-stimulated hamster alveolar macrophages release interleukin-1.

A Suwabe¹, K Takahashi, S Yasui, S Arai, F Sendo.

Abstract

The capacity of alveolar macrophages (AM) of bleomycin-instilled hamsters to proliferate mouse thymocytes (interleukin-1 activity) and hamster fibroblasts (fibroblast proliferation (FP) activity was studied. Using bleomycin-instilled hamsters, the FP activity of AM culture supernatants was increased significantly on days 1, 5, and 10 after instillation of bleomycin. The interleukin-1 (IL-1) activity, however, was increased significantly on day 1 only as compared with saline-treated hamsters. Next, normal AM were stimulated in vitro by bleomycin. After being fractionated by chromatography, their culture supernatant showed IL-1 activity, which also indicated FP activity. These results suggest that bleomycin directly stimulates AM to release IL-1 in the fibrogenic responses.

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Year: 1988 PMID： 2458043 PMCID： PMC1880746

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

33 in total

1. Separation of mouse thymocytes into two subpopulations by the use of peanut agglutinin.

Authors: Y Reisner; M Linker-Israeli; N Sharon
Journal: Cell Immunol Date: 1976-07 Impact factor: 4.868

2. Physiological quiescence in plasma-derived serum: influence of platelet-derived growth factor on cell growth in culture.

Authors: R Ross; C Nist; B Kariya; M J Rivest; E Raines; J Callis
Journal: J Cell Physiol Date: 1978-12 Impact factor: 6.384

3. Studies on pulmonary alveolar macrophages from the normal rabbit: a technique to procure them in a high state of purity.

Authors: Q MYRVIK; E S LEAKE; B FARISS
Journal: J Immunol Date: 1961-02 Impact factor: 5.422

4. The in-vitro effects of silica-treated hamster macrophages on collagen production by hamster fibroblasts.

Authors: J S Harington; M Ritchie; P C King; K Miller
Journal: J Pathol Date: 1973-01 Impact factor: 7.996

5. The development of bleomycin-induced pulmonary fibrosis in neutrophil-depleted and complement-depleted rats.

Authors: R S Thrall; S H Phan; J R McCormick; P A Ward
Journal: Am J Pathol Date: 1981-10 Impact factor: 4.307

6. Cytokine-dependent thymocyte responses: characterization of IL 1 and IL 2 target subpopulations and mechanism of action.

Authors: P J Conlon; C S Henney; S Gillis
Journal: J Immunol Date: 1982-02 Impact factor: 5.422

7. Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin. Lung volumes, volume-pressure relations, carbon monoxide uptake, and arterial blood gas studied.

Authors: G L Snider; B R Celli; R H Goldstein; J J O'Brien; E C Lucey
Journal: Am Rev Respir Dis Date: 1978-02

Bleomycin-stimulated hamster alveolar macrophages release interleukin-1.

1. Separation of mouse thymocytes into two subpopulations by the use of peanut agglutinin.

2. Physiological quiescence in plasma-derived serum: influence of platelet-derived growth factor on cell growth in culture.

3. Studies on pulmonary alveolar macrophages from the normal rabbit: a technique to procure them in a high state of purity.

4. The in-vitro effects of silica-treated hamster macrophages on collagen production by hamster fibroblasts.

5. The development of bleomycin-induced pulmonary fibrosis in neutrophil-depleted and complement-depleted rats.

6. Cytokine-dependent thymocyte responses: characterization of IL 1 and IL 2 target subpopulations and mechanism of action.

7. Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin. Lung volumes, volume-pressure relations, carbon monoxide uptake, and arterial blood gas studied.

8. Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin: pathology and stereology.

9. A macrophage-dependent factor that stimulates the proliferation of fibroblasts in vitro.

10. Human alveolar macrophage-derived chemotactic factor for neutrophils. Stimuli and partial characterization.

1. FTS reduces bleomycin-induced cytokine and chemokine production and inhibits pulmonary fibrosis in mice.

2. Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells.

3. Decreased prostaglandin E2 synthesis by lung fibroblasts isolated from rats with bleomycin-induced lung fibrosis.

4. Cells containing factor XIIIa and pulmonary fibrosis induced by bleomycin.

5. Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice.

6. The pneumotoxicant paraquat potentiates IL-1 and TNF production by human mononuclear cells.

7. Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis.