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Literature DB >> 2085143

Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells.

M Bianchi¹, A Mantovani, A Erroi, C A Dinarello, P Ghezzi.

Abstract

We have studied the effect of Ambroxol on the production of Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) in human mononuclear cells (MNC). For this purpose MNC were cultured for 24 h in the presence of endotoxin and different doses of Ambroxol. The results indicate that Ambroxol markedly inhibited IL-1 and TNF production at doses of 10-100 microgram ml, without any apparent toxicity.

Entities: Chemical Disease Gene Species

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Year: 1990 PMID： 2085143 DOI： 10.1007/BF01997619

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

16 in total

1. Ambroxol and pulmonary toxicity induced by antineoplastic drugs.

Authors: M Luisetti; V Peona; M Salmona; A M Pagnoni; F Villani; R Knerich; M Genghini; L Abbà; E Pozzi
Journal: Int J Clin Pharmacol Res Date: 1986

2. Prostaglandins posttranscriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate.

Authors: P J Knudsen; C A Dinarello; T B Strom
Journal: J Immunol Date: 1986-11-15 Impact factor: 5.422

Review 3. Cachectin and tumour necrosis factor as two sides of the same biological coin.

Authors: B Beutler; A Cerami
Journal: Nature Date: 1986 Apr 17-23 Impact factor: 49.962

4. Silica-stimulated monocytes release fibroblast proliferation factors identical to interleukin 1. A potential role for interleukin 1 in the pathogenesis of silicosis.

Authors: J A Schmidt; C N Oliver; J L Lepe-Zuniga; I Green; I Gery
Journal: J Clin Invest Date: 1984-05 Impact factor: 14.808

Review 5. Interleukin-1.

Authors: C A Dinarello
Journal: Rev Infect Dis Date: 1984 Jan-Feb

6. Dexamethasone inhibition of interleukin 1 beta production by human monocytes. Posttranscriptional mechanisms.

Authors: J A Kern; R J Lamb; J C Reed; R P Daniele; P C Nowell
Journal: J Clin Invest Date: 1988-01 Impact factor: 14.808

7. Concentrations of immunoreactive human tumor necrosis factor alpha produced by human mononuclear cells in vitro.

Authors: J W van der Meer; S Endres; G Lonnemann; J G Cannon; T Ikejima; S Okusawa; J A Gelfand; C A Dinarello
Journal: J Leukoc Biol Date: 1988-03 Impact factor: 4.962

8. Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance.

Authors: B Beutler; N Krochin; I W Milsark; C Luedke; A Cerami
Journal: Science Date: 1986-05-23 Impact factor: 47.728

9. Ameliorating effect of murine interferon gamma on bleomycin-induced lung collagen fibrosis in mice.

Authors: S N Giri; D M Hyde; B J Marafino
Journal: Biochem Med Metab Biol Date: 1986-10

10. Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis.

Authors: P F Piguet; M A Collart; G E Grau; Y Kapanci; P Vassalli
Journal: J Exp Med Date: 1989-09-01 Impact factor: 14.307

5 in total

1. Ambroxol - Resurgence of an old molecule as an anti-inflammatory agent in chronic obstructive airway diseases.

Authors: P R Gupta
Journal: Lung India Date: 2010-04

2. Identification and characterization of ambroxol as an enzyme enhancement agent for Gaucher disease.

Authors: Gustavo H B Maegawa; Michael B Tropak; Justin D Buttner; Brigitte A Rigat; Maria Fuller; Deepangi Pandit; Liangiie Tang; Gregory J Kornhaber; Yoshitomo Hamuro; Joe T R Clarke; Don J Mahuran
Journal: J Biol Chem Date: 2009-07-03 Impact factor: 5.157