OBJECTIVES: To explore associations between serum 25-hydroxyvitamin D (25(OH)D) levels and a wide range of health conditions, physical performance measures, disability, and mortality in a large epidemiological study to identify an optimum range for 25(OH)D concentrations. DESIGN: Cross-sectional study, with additional prospective data on falls and mortality. SETTING: Concord Health and Ageing in Men Project, Sydney, Australia. PARTICIPANTS: Community-dwelling men aged 70 and older (N = 1,659). MEASUREMENTS: Serum 25(OH)D levels, general health status, self-reported diseases, physical performance measures, disability (activities of daily living and instrumental activities of daily living) and falls. RESULTS: Fair, poor, and very poor health; self-reported diabetes mellitus; hyperglycemia; depression; muscle weakness; poor balance; and all-cause mortality were all associated with serum 25(OH)D levels less than 50 nmol/L, even after adjustment for confounding. The findings also suggest that, in older men, for a wide range of health conditions, physical performance measures, disability, falls, and mortality, the optimum range of 25(OH)D is between 50.0 and 74.9 nmol/L, with no additional benefit for 25(OH)D levels of 75.0 nmol/L or greater. CONCLUSION: Programs aimed at achieving an optimum range of serum 25(OH)D at levels between 50.0 and 74.9 nmol/L may have overall health benefits and such levels are adequate for older men.
OBJECTIVES: To explore associations between serum 25-hydroxyvitamin D (25(OH)D) levels and a wide range of health conditions, physical performance measures, disability, and mortality in a large epidemiological study to identify an optimum range for 25(OH)D concentrations. DESIGN: Cross-sectional study, with additional prospective data on falls and mortality. SETTING: Concord Health and Ageing in Men Project, Sydney, Australia. PARTICIPANTS: Community-dwelling men aged 70 and older (N = 1,659). MEASUREMENTS: Serum 25(OH)D levels, general health status, self-reported diseases, physical performance measures, disability (activities of daily living and instrumental activities of daily living) and falls. RESULTS: Fair, poor, and very poor health; self-reported diabetes mellitus; hyperglycemia; depression; muscle weakness; poor balance; and all-cause mortality were all associated with serum 25(OH)D levels less than 50 nmol/L, even after adjustment for confounding. The findings also suggest that, in older men, for a wide range of health conditions, physical performance measures, disability, falls, and mortality, the optimum range of 25(OH)D is between 50.0 and 74.9 nmol/L, with no additional benefit for 25(OH)D levels of 75.0 nmol/L or greater. CONCLUSION: Programs aimed at achieving an optimum range of serum 25(OH)D at levels between 50.0 and 74.9 nmol/L may have overall health benefits and such levels are adequate for older men.
Authors: Toni L Glover; Burel R Goodin; Christopher D King; Kimberly T Sibille; Matthew S Herbert; Adriana S Sotolongo; Yenisel Cruz-Almeida; Emily J Bartley; Hailey W Bulls; Ann L Horgas; David T Redden; Joseph L Riley; Roland Staud; Barri J Fessler; Laurence A Bradley; Roger B Fillingim Journal: Clin J Pain Date: 2015-12 Impact factor: 3.442
Authors: Michelle Shardell; Richard D Semba; Rita R Kalyani; Gregory E Hicks; Stefania Bandinelli; Luigi Ferrucci Journal: J Gerontol A Biol Sci Med Sci Date: 2015-03-07 Impact factor: 6.053
Authors: N A Perigo Nascimento; P F P Moreira; R V Marin; L D F Moreira; M Lazaretti Castro; C A F Santos; C M A Filho; M Seabra Cendoroglo Journal: J Nutr Health Aging Date: 2016-04 Impact factor: 4.075