Literature DB >> 24575973

Recent studies of genetic dysfunction in pelvic organ prolapse: the role of collagen defects.

Veronica F Lim1, John K Khoo, Vivien Wong, Kate H Moore.   

Abstract

Gynaecologists are becoming increasingly aware that women with a family history of prolapse are at an increased risk of prolapse refractory to treatment. In the past five years, several genetic mutations have been shown to correlate with increased prolapse susceptibility. These mutations can result in disordered collagen metabolism, which weaken the fascial support of the pelvic organs. This review examines the contemporary evidence regarding the role of collagen in prolapse.
© 2014 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.

Entities:  

Keywords:  collagen; genetic influences; immunohistochemistry; pelvic organ prolapse

Mesh：

Substances：

Year:  2014        PMID： 24575973     DOI： 10.1111/ajo.12169

Source DB:  PubMed          Journal:  Aust N Z J Obstet Gynaecol        ISSN： 0004-8666            Impact factor:   2.100


  14 in total

1.  Transcriptional Regulation of Connective Tissue Metabolism Genes in Women With Pelvic Organ Prolapse.

Authors:  Ali Borazjani; Nathan Kow; Samantha Harris; Beri Ridgeway; Margot S Damaser
Journal:  Female Pelvic Med Reconstr Surg       Date:  2017 Jan/Feb       Impact factor: 2.091

2.  Polymorphism rs1800255 from COL3A1 gene and the risk for pelvic organ prolapse.

Authors:  Fernando Henrique Teixeira; César Eduardo Fernandes; Ricardo Peres do Souto; Emerson de Oliveira
Journal:  Int Urogynecol J       Date:  2019-04-30       Impact factor: 2.894

Review 3.  The difference in collagen type-1 expression in women with and without pelvic organ prolapse: a systematic review and meta-analysis.

Authors:  Akbar Novan Dwi Saputra; Dicky Moch Rizal; Sarrah Ayuandari; Nuring Pangastuti
Journal:  Int Urogynecol J       Date:  2022-05-21       Impact factor: 1.932

4.  Advancing our understanding of genetic risk factors and potential personalized strategies for pelvic organ prolapse.

Authors:  Reedik Mägi; Triin Laisk; Natàlia Pujol-Gualdo; Kristi Läll; Maarja Lepamets; Henna-Riikka Rossi; Riikka K Arffman; Terhi T Piltonen
Journal:  Nat Commun       Date:  2022-06-23       Impact factor: 17.694

5.  Smooth Muscle Progenitor Cells Derived From Human Pluripotent Stem Cells Induce Histologic Changes in Injured Urethral Sphincter.

Authors:  Yanhui Li; Yan Wen; Zhe Wang; Yi Wei; Prachi Wani; Morgaine Green; Ganesh Swaminathan; Anand Ramamurthi; Renee Reijo Pera; Bertha Chen
Journal:  Stem Cells Transl Med       Date:  2016-07-26       Impact factor: 6.940

6.  Pelvic floor disorder symptoms and bone strength in postmenopausal women.

Authors:  Isuzu Meyer; Sarah L Morgan; Alayne D Markland; Jeff M Szychowski; Holly E Richter
Journal:  Int Urogynecol J       Date:  2020-02-29       Impact factor: 2.894

7.  Identification of Differentially Expressed Genes in Pelvic Organ Prolapse by RNA-Seq.

Authors:  Ruoyun Xie; Ying Xu; Shuixiu Fan; Yanfeng Song
Journal:  Med Sci Monit       Date:  2016-11-07

8.  Advanced glycation end products decrease collagen I levels in fibroblasts from the vaginal wall of patients with POP via the RAGE, MAPK and NF-κB pathways.

Authors:  Yi-Song Chen; Xiao-Juan Wang; Weiwei Feng; Ke-Qin Hua
Journal:  Int J Mol Med       Date:  2017-08-11       Impact factor: 4.101

9.  Expression changes in pelvic organ prolapse: a systematic review and in silico study.

Authors:  Maryam B Khadzhieva; Dmitry S Kolobkov; Svetlana V Kamoeva; Lyubov E Salnikova
Journal:  Sci Rep       Date:  2017-08-09       Impact factor: 4.379

10.  Effects of Oxytocin for Induction and Augmentation of Labor on Pelvic Floor Symptoms and Support in the Postpartum Period.

Authors:  Lauren Nicola; Jingye Yang; Marlene J Egger; Ingrid E Nygaard
Journal:  Female Pelvic Med Reconstr Surg       Date:  2021-05-01       Impact factor: 2.091
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