Literature DB >> 2457116

Antigenic variation of neutralization-sensitive epitopes of caprine arthritis-encephalitis lentivirus during persistent arthritis.

T C McGuire1, L K Norton, K I O'Rourke, W P Cheevers.   

Abstract

Caprine arthritis-encephalitis virus (CAEV), a naturally occurring lentivirus of goats, causes disease characterized by virus persistence and recurrent arthritis. These studies demonstrate in vitro neutralization of CAEV infectivity by serum from goats infected with CAEV. Serum neutralizing activity was not detectable until 10 to 36 months postinfection, and titers were relatively low (less than or equal to 1:8). Serum neutralization was caused by antibody and was virus specific. Antigenic variants of CAEV were isolated from cell-free joint fluid of arthritic goats 9 to 18 months postinfection. The delayed appearance of neutralizing antibody and the subsequent development of antigenic variants may promote CAEV persistence in vivo and provide a stimulus for recurrent arthritis.

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Year:  1988        PMID： 2457116      PMCID： PMC253474     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  33 in total

1.  Deficient LAV1 neutralising capacity of sera from patients with AIDS or related syndromes.

Authors:  F Clavel; D Klatzmann; L Montagnier
Journal:  Lancet       Date:  1985-04-13       Impact factor: 79.321

2.  Slow virus visna: reproduction in vitro of virus from extrachromosomal DNA.

Authors:  J D Harris; H Blum; J Scott; B Traynor; P Ventura; A Haase
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

3.  Antigenic variation during persistent infection by equine infectious anemia virus, a retrovirus.

Authors:  R C Montelaro; B Parekh; A Orrego; C J Issel
Journal:  J Biol Chem       Date:  1984-08-25       Impact factor: 5.157

4.  Immune rabbit sera do not recognize antigenic variants of caprine arthritis-encephalitis virus isolated during persistent infection.

Authors:  L W Anderson; P Klevjer-Anderson; T C McGuire
Journal:  Infect Immun       Date:  1983-11       Impact factor: 3.441

Review 5.  Lentiviral diseases of sheep and goats: chronic pneumonia leukoencephalomyelitis and arthritis.

Authors:  O Narayan; L C Cork
Journal:  Rev Infect Dis       Date:  1985 Jan-Feb

6.  Augmented T lymphocyte responses and abnormal B lymphocyte numbers in goats chronically infected with the retrovirus causing caprine arthritis-encephalitis.

Authors:  J C DeMartini; K L Banks; A Greenlee; D S Adams; T C McGuire
Journal:  Am J Vet Res       Date:  1983-11       Impact factor: 1.156

7.  Lack of neutralizing antibodies to caprine arthritis-encephalitis lentivirus in persistently infected goats can be overcome by immunization with inactivated Mycobacterium tuberculosis.

Authors:  O Narayan; D Sheffer; D E Griffin; J Clements; J Hess
Journal:  J Virol       Date:  1984-02       Impact factor: 5.103

8.  A sequential study of virus expression in retrovirus-induced arthritis of goats.

Authors:  P Klevjer-Anderson; D S Adams; L W Anderson; K L Banks; T C McGuire
Journal:  J Gen Virol       Date:  1984-09       Impact factor: 3.891

9.  Pronounced production of polyclonal immunoglobulin G1 in the synovial fluid of goats with caprine arthritis-encephalitis virus infection.

Authors:  G C Johnson; D S Adams; T C McGuire
Journal:  Infect Immun       Date:  1983-08       Impact factor: 3.441

10.  Preferential immune response to virion surface glycoproteins by caprine arthritis-encephalitis virus-infected goats.

Authors:  G C Johnson; A F Barbet; P Klevjer-Anderson; T C McGuire
Journal:  Infect Immun       Date:  1983-08       Impact factor: 3.441
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  12 in total

1.  Type 1 and type 2 cytokine gene expression by viral gp135 surface protein-activated T lymphocytes in caprine arthritis-encephalitis lentivirus infection.

Authors:  W P Cheevers; J C Beyer; D P Knowles
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

2.  Immune reconstitution prevents continuous equine infectious anemia virus replication in an Arabian foal with severe combined immunodeficiency: lessons for control of lentiviruses.

Authors:  R H Mealey; D G Fraser; J L Oaks; G H Cantor; T C McGuire
Journal:  Clin Immunol       Date:  2001-11       Impact factor: 3.969

3.  Epitope analysis of capsid and matrix proteins of North American ovine lentivirus field isolates.

Authors:  K A Marcom; L D Pearson; C S Chung; J M Poulson; J C DeMartini
Journal:  J Clin Microbiol       Date:  1991-07       Impact factor: 5.948

4.  Variability and immunogenicity of caprine arthritis-encephalitis virus surface glycoprotein.

Authors:  S Valas; C Benoit; C Baudry; G Perrin; R Z Mamoun
Journal:  J Virol       Date:  2000-07       Impact factor: 5.103

Review 5.  Molecular biology and pathogenesis of animal lentivirus infections.

Authors:  J E Clements; M C Zink
Journal:  Clin Microbiol Rev       Date:  1996-01       Impact factor: 26.132

6.  Pathogenic mechanisms of caprine arthritis-encephalitis virus.

Authors:  E G Mdurvwa; P O Ogunbiyi; H S Gakou; P G Reddy
Journal:  Vet Res Commun       Date:  1994       Impact factor: 2.459

7.  Structure and genetic variability of envelope glycoproteins of two antigenic variants of caprine arthritis-encephalitis lentivirus.

Authors:  D P Knowles; W P Cheevers; T C McGuire; A L Brassfield; W G Harwood; T A Stem
Journal:  J Virol       Date:  1991-11       Impact factor: 5.103

8.  Severity of arthritis is predicted by antibody response to gp135 in chronic infection with caprine arthritis-encephalitis virus.

Authors:  D Knowles; W Cheevers; T McGuire; T Stem; J Gorham
Journal:  J Virol       Date:  1990-05       Impact factor: 5.103

9.  Glycosylation of immunodominant linear epitopes in the carboxy-terminal region of the caprine arthritis-encephalitis virus surface envelope enhances vaccine-induced type-specific and cross-reactive neutralizing antibody responses.

Authors:  J D Trujillo; N M Kumpula-McWhirter; K J Hötzel; M Gonzalez; W P Cheevers
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

10.  Transmembrane protein oligomers of caprine arthritis-encephalitis lentivirus are immunodominant in goats with progressive arthritis.

Authors:  T C McGuire; D P Knowles; W C Davis; A L Brassfield; T A Stem; W P Cheevers
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103
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