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Literature DB >> 2457067

Monoclonal antibodies directed against human immunodeficiency virus (HIV) gag proteins with specificity for conserved epitopes in HIV-1, HIV-2 and simian immunodeficiency virus.

M Niedrig¹, J P Rabanus, J L'Age Stehr, H R Gelderblom, G Pauli.

Abstract

Monoclonal antibodies (MAbs) were raised against gag proteins of human immunodeficiency virus type 1 (HIV-1), strain HTLV-IIIB. One of 29 antibodies was specific for p17 of HIV-1. Twenty of 28 MAbs reactive with the major core protein p24 of HIV-1 showed cross-reactivity with HIV-2, and five of these also detected the corresponding antigens of simian immunodeficiency virus (SIVmac). The MAbs were reactive in several tests, i.e. ELISA, immunostaining of Western blots, immunofluorescence, alkaline phosphatase-anti-alkaline phosphatase immunocytochemistry and immunoelectron microscopy. The submembrane protein p17 was clearly localized within the virion.

Entities: Disease Gene Species

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Year: 1988 PMID： 2457067 DOI： 10.1099/0022-1317-69-8-2109

Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891

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Cited

17 in total

1. Expression of nef, vpu, CA and CD4 during the infection of lymphoid and monocytic cell lines with HIV-1.

Authors: T Schneider; P Hildebrandt; K Rokos; U Schubert; W Rönspeck; C Grund; A Beck; R Blesken; G Kulins; H Oldenburg
Journal: Arch Virol Date: 1992 Impact factor: 2.574

2. Infection of the human monocytic cell line Mono Mac6 with human immunodeficiency virus types 1 and 2 results in long-term production of virus variants with increased cytopathogenicity for CD4+ T cells.

Authors: J L'age-Stehr; M Niedrig; H R Gelderblom; J W Sim-Brandenburg; M Urban-Schriefer; E P Rieber; J G Haas; G Riethmüller; H W Ziegler-Heitbrock
Journal: J Virol Date: 1990-08 Impact factor: 5.103

3. Epitope mapping of monoclonal antibodies against human immunodeficiency virus type 1 structural proteins by using peptides.

Authors: M Niedrig; J Hinkula; W Weigelt; J L'age-Stehr; G Pauli; J Rosen; B Wahren
Journal: J Virol Date: 1989-08 Impact factor: 5.103

4. Molecular cloning of two west African human immunodeficiency virus type 2 isolates that replicate well in macrophages: a Gambian isolate, from a patient with neurologic acquired immunodeficiency syndrome, and a highly divergent Ghanian isolate.

Authors: H Kühnel; H von Briesen; U Dietrich; M Adamski; D Mix; L Biesert; R Kreutz; A Immelmann; K Henco; C Meichsner
Journal: Proc Natl Acad Sci U S A Date: 1989-04 Impact factor: 11.205

5. Multiple effects of codon usage optimization on expression and immunogenicity of DNA candidate vaccines encoding the human immunodeficiency virus type 1 Gag protein.

Authors: L Deml; A Bojak; S Steck; M Graf; J Wild; R Schirmbeck; H Wolf; R Wagner
Journal: J Virol Date: 2001-11 Impact factor: 5.103

6. Selection of recombinant, library-derived antibody fragments against p24 for human immunodeficiency virus type 1 diagnostics.

Authors: H J de Haard; B Kazemier; M J Koolen; L J Nijholt; R H Meloen; B van Gemen; H R Hoogenboom; J W Arends
Journal: Clin Diagn Lab Immunol Date: 1998-09

10. Follicular dendritic cells are a major reservoir for human immunodeficiency virus type 1 in lymphoid tissues facilitating infection of CD4+ T-helper cells.

Authors: H Spiegel; H Herbst; G Niedobitek; H D Foss; H Stein
Journal: Am J Pathol Date: 1992-01 Impact factor: 4.307