Yan Wisnu Prajoko1, Teguh Aryandono. 1. Department of Surgery, Faculty of Medicine, Diponegoro University, Tembalang Semarang, Indonesia E-mail : ywp.surgonco75@gmail.com.
Abstract
BACKGROUND: NF-κB inhibits apoptosis through induction of antiapoptotic proteins and suppression of proapoptotic genes. Various chemotherapy agents induce NF-κB translocation and target gene activation. We conducted the present study to assess the predictive value of NF-κB regarding pathologic responses after receiving neoadjuvant chemotherapy. MATERIALS AND METHODS: We enrolled 131 patients with locally advanced invasive ductal breast carcinoma. Immunohistochemistry (IHC) was used to detect NF-κB expression. Evaluation of pathologic response was elaborated with the Ribero classification. RESULTS: Expression of NF-κB was significantly associated with poor pathological response (p=0.02). From the multivariate analysis, it was found that the positive expression of NF-κB yielded RR=1.74 (95%CI 0.77 to 3.94). CONCLUSIONS: NF-κB can be used as a predictor of poor pathological response after neoadjuvant chemotherapy.
BACKGROUND: NF-κB inhibits apoptosis through induction of antiapoptotic proteins and suppression of proapoptotic genes. Various chemotherapy agents induce NF-κB translocation and target gene activation. We conducted the present study to assess the predictive value of NF-κB regarding pathologic responses after receiving neoadjuvant chemotherapy. MATERIALS AND METHODS: We enrolled 131 patients with locally advanced invasive ductal breast carcinoma. Immunohistochemistry (IHC) was used to detect NF-κB expression. Evaluation of pathologic response was elaborated with the Ribero classification. RESULTS: Expression of NF-κB was significantly associated with poor pathological response (p=0.02). From the multivariate analysis, it was found that the positive expression of NF-κB yielded RR=1.74 (95%CI 0.77 to 3.94). CONCLUSIONS: NF-κB can be used as a predictor of poor pathological response after neoadjuvant chemotherapy.
Authors: José Esparza-López; Ossian Longoria; Eliseo Neftali De La Cruz-Escobar; Julio Cesar Garibay-Díaz; Eucario León-Rodríguez; María De Jesús Ibarra-Sánchez Journal: Oncol Lett Date: 2021-12-16 Impact factor: 2.967