Jeong Hee Yoon1, Jeong Min Lee, Joon Koo Han, Byung Ihn Choi. 1. Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea. jmsh@snu.ac.kr.
Abstract
OBJECTIVES: The purpose of this study was to determine the optimal minimum number of liver stiffness measurements on shear wave elastography (SWE) and to evaluate the frequency of technical failures and unreliable stiffness measurements and the intraobserver reproducibility of SWE. METHODS: This retrospective study was approved by our Institutional Review Board, and informed consent was waived. From August 2011 to January 2013, 540 patients underwent abdominal sonography, including SWE. In 86 patients (group 1), the minimum number of examinations was determined by comparing the intraclass correlation coefficient (ICC) of subsets of the first 2 to 14 measurements with that from 15 measurements. In 454 patients (group 2), 2 SWE sessions were performed in the right lobe within 1 day. Technical failure was defined as when no or little signal was obtained in the elastogram during the first 5 acquisitions; unreliable SWE results were defined as when the interquartile range/median liver stiffness value exceeded 30%. Intraobserver reproducibility was assessed using ICCs and Bland-Altman plots. RESULTS: In group 1, the ICCs did not significantly increase after the first 6 measurements. In group 2, there were technical failures and unreliable results in 47 patients (10.35%) and 74 patients (16.29%), respectively. In 407 patients, after excluding technical failures, there was no significant difference in the median liver stiffness values between the 2 sessions (6.95 versus 6.86 kPa; P > .05). The overall intraobserver reproducibility was excellent (ICC, 0.95). CONCLUSIONS: In this study, the optimal minimum number of SWE measurements was 6, and SWE using 6 measurements showed excellent intraobserver reproducibility.
OBJECTIVES: The purpose of this study was to determine the optimal minimum number of liver stiffness measurements on shear wave elastography (SWE) and to evaluate the frequency of technical failures and unreliable stiffness measurements and the intraobserver reproducibility of SWE. METHODS: This retrospective study was approved by our Institutional Review Board, and informed consent was waived. From August 2011 to January 2013, 540 patients underwent abdominal sonography, including SWE. In 86 patients (group 1), the minimum number of examinations was determined by comparing the intraclass correlation coefficient (ICC) of subsets of the first 2 to 14 measurements with that from 15 measurements. In 454 patients (group 2), 2 SWE sessions were performed in the right lobe within 1 day. Technical failure was defined as when no or little signal was obtained in the elastogram during the first 5 acquisitions; unreliable SWE results were defined as when the interquartile range/median liver stiffness value exceeded 30%. Intraobserver reproducibility was assessed using ICCs and Bland-Altman plots. RESULTS: In group 1, the ICCs did not significantly increase after the first 6 measurements. In group 2, there were technical failures and unreliable results in 47 patients (10.35%) and 74 patients (16.29%), respectively. In 407 patients, after excluding technical failures, there was no significant difference in the median liver stiffness values between the 2 sessions (6.95 versus 6.86 kPa; P > .05). The overall intraobserver reproducibility was excellent (ICC, 0.95). CONCLUSIONS: In this study, the optimal minimum number of SWE measurements was 6, and SWE using 6 measurements showed excellent intraobserver reproducibility.
Authors: Yufeng Deng; Mark L Palmeri; Ned C Rouze; Stephen J Rosenzweig; Manal F Abdelmalek; Kathryn R Nightingale Journal: Ultrasound Med Biol Date: 2015-04-18 Impact factor: 2.998
Authors: Kathryn R Nightingale; Charles C Church; Gerald Harris; Keith A Wear; Michael R Bailey; Paul L Carson; Hui Jiang; Kurt L Sandstrom; Thomas L Szabo; Marvin C Ziskin Journal: J Ultrasound Med Date: 2015-07 Impact factor: 2.153