Jamie Merves1, Amanda Muir1, Prasanna Modayur Chandramouleeswaran1, Antonella Cianferoni2, Mei-Lun Wang1, Jonathan M Spergel3. 1. Division of Gastroenterology and Nutrition, The Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia. 2. Division of Allergy and Immunology, The Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia. 3. Division of Allergy and Immunology, The Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia. Electronic address: spergel@email.chop.edu.
Abstract
OBJECTIVE: To review the understanding of the pathogenesis of eosinophilic esophagitis (EoE) and the role of the immune system in the disease process. DATA SOURCES: Peer-reviewed articles on EoE from PubMed searching for "Eosinophilic Esophagitis and fibrosis" in the period of 1995 to 2013. STUDY SELECTIONS: Studies on the clinical and immunologic features, pathogenesis, and management of EoE. RESULTS: Recent work has revealed that thymic stromal lymphopoietin and basophil have an increased role in the pathogenesis of disease. Additional understanding on the role of fibrosis in EoE is emerging. CONCLUSION: The incidence of EoE is increasing like most atopic disease. Similar to other allergic diseases, EoE is treated with topical steroids and/or allergen avoidance.
OBJECTIVE: To review the understanding of the pathogenesis of eosinophilic esophagitis (EoE) and the role of the immune system in the disease process. DATA SOURCES: Peer-reviewed articles on EoE from PubMed searching for "Eosinophilic Esophagitis and fibrosis" in the period of 1995 to 2013. STUDY SELECTIONS: Studies on the clinical and immunologic features, pathogenesis, and management of EoE. RESULTS: Recent work has revealed that thymic stromal lymphopoietin and basophil have an increased role in the pathogenesis of disease. Additional understanding on the role of fibrosis in EoE is emerging. CONCLUSION: The incidence of EoE is increasing like most atopic disease. Similar to other allergic diseases, EoE is treated with topical steroids and/or allergen avoidance.
Authors: James J Tomasek; Giulio Gabbiani; Boris Hinz; Christine Chaponnier; Robert A Brown Journal: Nat Rev Mol Cell Biol Date: 2002-05 Impact factor: 94.444
Authors: Chris A Liacouras; Jonathan M Spergel; Eduardo Ruchelli; Ritu Verma; Maria Mascarenhas; Edisio Semeao; Jonathan Flick; Janice Kelly; Terry Brown-Whitehorn; Petar Mamula; Jonathan E Markowitz Journal: Clin Gastroenterol Hepatol Date: 2005-12 Impact factor: 11.382
Authors: J P Franciosi; K A Hommel; C W DeBrosse; A B Greenberg; A J Greenler; J P Abonia; M E Rothenberg; J W Varni Journal: Child Care Health Dev Date: 2011-06-15 Impact factor: 2.508
Authors: Carine Blanchard; Ning Wang; Keith F Stringer; Anil Mishra; Patricia C Fulkerson; J Pablo Abonia; Sean C Jameson; Cassie Kirby; Michael R Konikoff; Margaret H Collins; Mitchell B Cohen; Rachel Akers; Simon P Hogan; Amal H Assa'ad; Philip E Putnam; Bruce J Aronow; Marc E Rothenberg Journal: J Clin Invest Date: 2006-02 Impact factor: 14.808
Authors: Vassili Soumelis; Pedro A Reche; Holger Kanzler; Wei Yuan; Gina Edward; Bernhart Homey; Michel Gilliet; Steve Ho; Svetlana Antonenko; Annti Lauerma; Kathleen Smith; Daniel Gorman; Sandra Zurawski; Jon Abrams; Satish Menon; Terri McClanahan; Rene de Waal-Malefyt Rd; Fernando Bazan; Robert A Kastelein; Yong-Jun Liu Journal: Nat Immunol Date: 2002-06-10 Impact factor: 25.606
Authors: Evan S Dellon; Elizabeth T Jensen; Christopher F Martin; Nicholas J Shaheen; Michael D Kappelman Journal: Clin Gastroenterol Hepatol Date: 2013-09-11 Impact factor: 11.382
Authors: Kelly A Whelan; Jamie F Merves; Veronique Giroux; Koji Tanaka; Andy Guo; Prasanna M Chandramouleeswaran; Alain J Benitez; Kara Dods; Jianwen Que; Joanne C Masterson; Shahan D Fernando; Bridget C Godwin; Andres J Klein-Szanto; Kudakwashe Chikwava; Eduardo D Ruchelli; Kathryn E Hamilton; Amanda B Muir; Mei-Lun Wang; Glenn T Furuta; Gary W Falk; Jonathan M Spergel; Hiroshi Nakagawa Journal: Gut Date: 2016-02-16 Impact factor: 23.059