Literature DB >> 24566189

Activity of host antimicrobials against multidrug-resistant Acinetobacter baumannii acquiring colistin resistance through loss of lipopolysaccharide.

Meritxell García-Quintanilla1, Marina R Pulido, Patricia Moreno-Martínez, Reyes Martín-Peña, Rafael López-Rojas, Jerónimo Pachón, Michael J McConnell.   

Abstract

Acinetobacter baumannii can acquire resistance to the cationic peptide antibiotic colistin through complete loss of lipopolysaccharide (LPS) expression. The activities of the host cationic antimicrobials LL-37 and human lysozyme against multidrug-resistant clinical isolates of A. baumannii that acquired colistin resistance through lipopolysaccharide loss were characterized. We demonstrate that LL-37 has activity against strains lacking lipopolysaccharide that is similar to that of their colistin-sensitive parent strains, whereas human lysozyme has increased activity against colistin-resistant strains lacking LPS.

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Year:  2014        PMID： 24566189      PMCID： PMC3993257          DOI： 10.1128/AAC.02642-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  A helix-loop-helix peptide at the upper lip of the active site cleft of lysozyme confers potent antimicrobial activity with membrane permeabilization action.

Authors:  H R Ibrahim; U Thomas; A Pellegrini
Journal:  J Biol Chem       Date:  2001-09-17       Impact factor: 5.157

2.  The non-enzymatic microbicidal activity of lysozymes.

Authors:  K Düring; P Porsch; A Mahn; O Brinkmann; W Gieffers
Journal:  FEBS Lett       Date:  1999-04-23       Impact factor: 4.124

3.  A Biochemical and Serological Study of a Group of Identical Unidentifiable Gram-negative Bacilli from Human Sources.

Authors:  I G Schaub; F D Hauber
Journal:  J Bacteriol       Date:  1948-10       Impact factor: 3.490

4.  Successful treatment of septic shock due to pan-resistant Acinetobacter baumannii using combined antimicrobial therapy including tigecycline.

Authors:  F S Taccone; H Rodriguez-Villalobos; D De Backer; V De Moor; J Deviere; J-L Vincent; F Jacobs
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2006-04       Impact factor: 3.267

5.  An ELISA for hCAP-18, the cathelicidin present in human neutrophils and plasma.

Authors:  O Sørensen; J B Cowland; J Askaa; N Borregaard
Journal:  J Immunol Methods       Date:  1997-08-07       Impact factor: 2.303

Review 6.  A comprehensive summary of LL-37, the factotum human cathelicidin peptide.

Authors:  Dieter Vandamme; Bart Landuyt; Walter Luyten; Liliane Schoofs
Journal:  Cell Immunol       Date:  2012-11-29       Impact factor: 4.868

7.  Cationic polypeptides are required for antibacterial activity of human airway fluid.

Authors:  Alexander M Cole; Hsiang-I Liao; Olga Stuchlik; Jason Tilan; Jan Pohl; Tomas Ganz
Journal:  J Immunol       Date:  2002-12-15       Impact factor: 5.422

Review 8.  LL-37, the only human member of the cathelicidin family of antimicrobial peptides.

Authors:  Ulrich H N Dürr; U S Sudheendra; Ayyalusamy Ramamoorthy
Journal:  Biochim Biophys Acta       Date:  2006-04-04

9.  Lipopolysaccharide-deficient Acinetobacter baumannii shows altered signaling through host Toll-like receptors and increased susceptibility to the host antimicrobial peptide LL-37.

Authors:  Jennifer H Moffatt; Marina Harper; Ashley Mansell; Bethany Crane; Timothy C Fitzsimons; Roger L Nation; Jian Li; Ben Adler; John D Boyce
Journal:  Infect Immun       Date:  2012-12-17       Impact factor: 3.441

10.  [Clonal diversity and antimicrobial susceptibility of Acinetobacter baumannii isolated in Spain. A nationwide multicenter study: GEIH-Ab project (2000)].

Authors:  Felipe Fernández-Cuenca; Alvaro Pascual; Anna Ribera; Jordi Vila; Germán Bou; José Miguel Cisneros; Jesús Rodríguez-Baño; Jerónimo Pachón; Luis Martínez-Martínez
Journal:  Enferm Infecc Microbiol Clin       Date:  2004-05       Impact factor: 1.731
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  15 in total

1.  Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii.

Authors:  Meritxell García-Quintanilla; José M Caro-Vega; Marina R Pulido; Patricia Moreno-Martínez; Jerónimo Pachón; Michael J McConnell
Journal:  Antimicrob Agents Chemother       Date:  2016-07-22       Impact factor: 5.191

2.  Colistin resistance mechanisms in Klebsiella pneumoniae strains from Taiwan.

Authors:  Yi-Hsiang Cheng; Tzu-Lung Lin; Yi-Jiun Pan; Yu-Ping Wang; Yi-Tsung Lin; Jin-Town Wang
Journal:  Antimicrob Agents Chemother       Date:  2015-02-17       Impact factor: 5.191

3.  An Amphipathic Undecapeptide with All d-Amino Acids Shows Promising Activity against Colistin-Resistant Strains of Acinetobacter baumannii and a Dual Mode of Action.

Authors:  Alberto Oddo; Thomas T Thomsen; Susanne Kjelstrup; Ciara Gorey; Henrik Franzyk; Niels Frimodt-Møller; Anders Løbner-Olesen; Paul R Hansen
Journal:  Antimicrob Agents Chemother       Date:  2015-11-16       Impact factor: 5.191

4.  Resistant mechanisms and molecular epidemiology of imipenem-resistant Acinetobacter baumannii.

Authors:  Shu-Zhen Xiao; Hai-Qing Chu; Li-Zhong Han; Zhe-Min Zhang; Bing Li; Lan Zhao; Liyun Xu
Journal:  Mol Med Rep       Date:  2016-07-22       Impact factor: 2.952

5.  Expanding the potential of NAI-107 for treating serious ESKAPE pathogens: synergistic combinations against Gram-negatives and bactericidal activity against non-dividing cells.

Authors:  Cristina Brunati; Thomas T Thomsen; Eleonora Gaspari; Sonia Maffioli; Margherita Sosio; Daniela Jabes; Anders Løbner-Olesen; Stefano Donadio
Journal:  J Antimicrob Chemother       Date:  2018-02-01       Impact factor: 5.790

Review 6.  The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-Biofilm Agent.

Authors:  Kylen E Ridyard; Joerg Overhage
Journal:  Antibiotics (Basel)       Date:  2021-05-29

Review 7.  Potential Use of Antimicrobial Peptides as Vaginal Spermicides/Microbicides.

Authors:  Nongnuj Tanphaichitr; Nopparat Srakaew; Rhea Alonzi; Wongsakorn Kiattiburut; Kessiri Kongmanas; Ruina Zhi; Weihua Li; Mark Baker; Guanshun Wang; Duane Hickling
Journal:  Pharmaceuticals (Basel)       Date:  2016-03-11

8.  Candidacidal Activity of Selected Ceragenins and Human Cathelicidin LL-37 in Experimental Settings Mimicking Infection Sites.

Authors:  Bonita Durnaś; Urszula Wnorowska; Katarzyna Pogoda; Piotr Deptuła; Marzena Wątek; Ewelina Piktel; Stanisław Głuszek; Xiaobo Gu; Paul B Savage; Katarzyna Niemirowicz; Robert Bucki
Journal:  PLoS One       Date:  2016-06-17       Impact factor: 3.240

Review 9.  Acinetobacter baumannii Infection and IL-17 Mediated Immunity.

Authors:  Zihe Yan; Junjun Yang; Renjing Hu; Xichi Hu; Kong Chen
Journal:  Mediators Inflamm       Date:  2016-02-09       Impact factor: 4.711

10.  In Vitro Synergistic Effects of Antimicrobial Combinations on Extensively Drug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Isolates.

Authors:  Hyukmin Lee; Kyung Ho Roh; Seong Geun Hong; Hee Bong Shin; Seok Hoon Jeong; Wonkeun Song; Young Uh; Dongeun Yong; Kyungwon Lee
Journal:  Ann Lab Med       Date:  2016-03       Impact factor: 3.464
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