Literature DB >> 24566176

Complete nucleotide sequences of two blaKPC-2-bearing IncN Plasmids isolated from sequence type 442 Klebsiella pneumoniae clinical strains four years apart.

Paula Juliana Pérez-Chaparro1, Louise Teixeira Cerdeira, Maíse Gomes Queiroz, Clayton Pereira Silva de Lima, Carlos Emílio Levy, Mónica Pavez, Nilton Lincopan, Evonnildo Costa Gonçalves, Elsa Masae Mamizuka, Jorge Luiz Mello Sampaio, Marcio Roberto Teixeira Nunes, John Anthony McCulloch.   

Abstract

We sequenced the oldest blaKPC-2-bearing plasmid isolated in Brazil and another plasmid also carried by a Klebsiella pneumoniae strain of sequence type 442 (ST442), isolated 52 months later. Both plasmids present an IncN backbone and few acquired regions. Because the 2005 plasmid presented deletions and a truncated gene within Tn4401b compared to the 2009 plasmid, we can thus infer that IncN blaKPC-2-bearing plasmids pFCF1305 and pFCF3SP had a common ancestor circulating in Brazil prior to May 2005.

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Year:  2014        PMID： 24566176      PMCID： PMC3993209          DOI： 10.1128/AAC.02341-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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