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Literature DB >> 2456579

A-type potassium channels expressed from Shaker locus cDNA.

L E Iverson¹, M A Tanouye, H A Lester, N Davidson, B Rudy.

Abstract

A-type K+ currents are expressed in Xenopus oocytes injected with in vitro-synthesized transcripts from cDNAs for the Drosophila Shaker (Sh) locus. A single Sh gene product, possibly as a multimer, is sufficient for formation of functional A channels. Various Sh RNAs express A currents with distinct kinetic properties. An analysis of structure-function relationships shows that the conserved central region of Sh polypeptides determines ionic selectivity and overall channel behavior, whereas the divergent amino and carboxyl termini can modify channel kinetics. Alternative splicing of Sh gene transcripts may provide one mechanism for the generation of K+ channel diversity.

Entities: Gene Species

Mesh：

Substances：

Year: 1988 PMID： 2456579 PMCID： PMC281833 DOI： 10.1073/pnas.85.15.5723

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

15 in total

1. Voltage clamp analysis of membrane currents in larval muscle fibers of Drosophila: alteration of potassium currents in Shaker mutants.

Authors: C F Wu; F N Haugland
Journal: J Neurosci Date: 1985-10 Impact factor: 6.167

2. Molecular model of the action potential sodium channel.

Authors: H R Guy; P Seetharamulu
Journal: Proc Natl Acad Sci U S A Date: 1986-01 Impact factor: 11.205

3. Single-channel and genetic analyses reveal two distinct A-type potassium channels in Drosophila.

Authors: C K Solc; W N Zagotta; R W Aldrich
Journal: Science Date: 1987-05-29 Impact factor: 47.728

4. Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel.

Authors: A Kamb; L E Iverson; M A Tanouye
Journal: Cell Date: 1987-07-31 Impact factor: 41.582

5. Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes.

Authors: L C Timpe; T L Schwarz; B L Tempel; D M Papazian; Y N Jan; L Y Jan
Journal: Nature Date: 1988-01-14 Impact factor: 49.962

6. Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila.

Authors: B L Tempel; D M Papazian; T L Schwarz; Y N Jan; L Y Jan
Journal: Science Date: 1987-08-14 Impact factor: 47.728

7. Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs.

Authors: P A Krieg; D A Melton
Journal: Nucleic Acids Res Date: 1984-09-25 Impact factor: 16.971

8. Genetic and voltage-clamp analysis of a Drosophila potassium channel.

Authors: L Salkoff
Journal: Cold Spring Harb Symp Quant Biol Date: 1983

9. Serotonin modulates a specific potassium current in the sensory neurons that show presynaptic facilitation in Aplysia.

Authors: M Klein; J Camardo; E R Kandel
Journal: Proc Natl Acad Sci U S A Date: 1982-09 Impact factor: 11.205

10. Existence of distinct sodium channel messenger RNAs in rat brain.

Authors: M Noda; T Ikeda; T Kayano; H Suzuki; H Takeshima; M Kurasaki; H Takahashi; S Numa
Journal: Nature Date: 1986 Mar 13-19 Impact factor: 49.962

57 in total

1. Unmasking of a novel potassium current in Drosophila by a mutation and drugs.

Authors: A Singh; S Singh
Journal: J Neurosci Date: 1999-08-15 Impact factor: 6.167

2. Sh and eag K(+) channel subunit interaction in frog oocytes depends on level and time of expression.

Authors: M L Chen; T Hoshi; C F Wu
Journal: Biophys J Date: 2000-09 Impact factor: 4.033

3. Interactions of membrane excitability mutations affecting potassium and sodium currents in the flight and giant fiber escape systems of Drosophila.

Authors: J E Engel; C F Wu
Journal: J Comp Physiol A Date: 1992-08 Impact factor: 1.836

A-type potassium channels expressed from Shaker locus cDNA.

1. Voltage clamp analysis of membrane currents in larval muscle fibers of Drosophila: alteration of potassium currents in Shaker mutants.

2. Molecular model of the action potential sodium channel.

3. Single-channel and genetic analyses reveal two distinct A-type potassium channels in Drosophila.

4. Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel.

5. Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes.

6. Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila.

7. Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs.

8. Genetic and voltage-clamp analysis of a Drosophila potassium channel.

9. Serotonin modulates a specific potassium current in the sensory neurons that show presynaptic facilitation in Aplysia.

10. Existence of distinct sodium channel messenger RNAs in rat brain.

1. Unmasking of a novel potassium current in Drosophila by a mutation and drugs.

2. Sh and eag K(+) channel subunit interaction in frog oocytes depends on level and time of expression.

3. Interactions of membrane excitability mutations affecting potassium and sodium currents in the flight and giant fiber escape systems of Drosophila.

Review 4. Use of Xenopus oocytes for the functional expression of plasma membrane proteins.

5. A role for hydrophobic residues in the voltage-dependent gating of Shaker K+ channels.

6. Two transient potassium currents in layer V pyramidal neurones from cat sensorimotor cortex.

7. Alternative splicing contributes to K+ channel diversity in the mammalian central nervous system.

Review 8. Oxidative modulation of voltage-gated potassium channels.

9. Epithelial K channel expressed in Xenopus oocytes is inactivated by protein kinase C.

10. A transient outward current in NG108-15 neuroblastoma x glioma hybrid cells.