[Pathogenesis of cataract after vitrectomy].

Cataract is the most common complication after vitrectomy. At first posterior subcapsular, it evolves into a nuclear type. A better understanding of the pathophysiologic mechanisms could help to develop strategies to prevent this complication. The main causative factors are oxidative stress, as evidenced by the persistence of an elevated partial pressure of oxygen in the lens after vitrectomy and the ionic changes in the lens. Mechanical factors may also be implicated: direct contact by gas tamponade or by silicone oil leads to desiccation cataract. The key of prevention of the formation of these cataracts is based on the reduction of oxidative stress.