| Literature DB >> 24561662 |
Yongmei Xu1, Chao Cai2, Kasemsiri Chandarajoti1, Po-Hung Hsieh1, Lingyun Li2, Truong Q Pham1, Erica M Sparkenbaugh3, Juzheng Sheng4, Nigel S Key3, Rafal Pawlinski3, Edward N Harris5, Robert J Linhardt2, Jian Liu1.
Abstract
Low-molecular-weight heparins (LMWHs) are carbohydrate-based anticoagulants clinically used to treat thrombotic disorders, but impurities, structural heterogeneity or functional irreversibility can limit treatment options. We report a series of synthetic LMWHs prepared by cost-effective chemoenzymatic methods. The high activity of one defined synthetic LMWH against human factor Xa (FXa) was reversible in vitro and in vivo using protamine, demonstrating that synthetically accessible constructs can have a critical role in the next generation of LMWHs.Entities:
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Year: 2014 PMID： 24561662 PMCID： PMC4393012 DOI： 10.1038/nchembio.1459
Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040