Literature DB >> 2456112

Simultaneous release by bradykinin of substance P- and calcitonin gene-related peptide immunoreactivities from capsaicin-sensitive structures in guinea-pig heart.

P Geppetti1, C A Maggi, F Perretti, S Frilli, S Manzini.   

Abstract

Both bradykinin and capsaicin infusion evoked a marked increase in the outflow of substance P- (SP-LI) and calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) from guinea-pig isolated, perfused heart. After acute exposure to capsaicin in vitro, or in hearts taken from animals pretreated in vivo with capsaicin, bradykinin failed to induce any release. The positive chronotropic effect of bradykinin was reduced after acute capsaicin administration. The effect of bradykinin in the guinea-pig heart could be mediated, at least partly, by release of neuropeptides from peripheral endings of capsaicin-sensitive sensory neurones.

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Year:  1988        PMID： 2456112      PMCID： PMC1854004          DOI： 10.1111/j.1476-5381.1988.tb11528.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  Multiple tachykinin pools in sensory nerve fibres in the rabbit iris.

Authors:  R Håkanson; B Beding; R Ekman; M Heilig; C Wahlestedt; F Sundler
Journal:  Neuroscience       Date:  1987-06       Impact factor: 3.590

2.  Substance P-like immunoreactivity in capsaicin-sensitive structures of the rat thymus.

Authors:  P Geppetti; C A Maggi; S Zecchi-Orlandini; P Santicioli; A Meli; S Frilli; M G Spillantini; F Amenta
Journal:  Regul Pept       Date:  1987-09

3.  Effects of capsaicin on release of substance P-like immunoreactivity and physiological parameters in isolated perfused guinea-pig heart.

Authors:  D B Hoover
Journal:  Eur J Pharmacol       Date:  1987-09-23       Impact factor: 4.432

4.  Action of peptides and other algesic agents on paravascular pain receptors of the isolated perfused rabbit ear.

Authors:  H Juan; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

5.  Changes in bradykinin level in coronary sinus blood after the experimental occlusion of a coronary artery.

Authors:  E Kimura; K Hashimoto; S Furukawa; H Hayakawa
Journal:  Am Heart J       Date:  1973-05       Impact factor: 4.749

6.  Ischaemia and changes in contractility induce release of calcitonin gene-related peptide but not neuropeptide Y from the isolated perfused guinea-pig heart.

Authors:  A Franco-Cereceda; A Saria; J M Lundberg
Journal:  Acta Physiol Scand       Date:  1987-10

7.  The effects of sensory denervation on the responses of the rabbit eye to prostaglandin E1, bradykinin and substance P.

Authors:  J M Butler; B R Hammond
Journal:  Br J Pharmacol       Date:  1980-07       Impact factor: 8.739

Review 8.  Pharmacology of bradykinin and related kinins.

Authors:  D Regoli; J Barabé
Journal:  Pharmacol Rev       Date:  1980-03       Impact factor: 25.468

9.  Stimulation by bradykinin of afferent vagal C-fibers with chemosensitive endings in the heart and aorta of the dog.

Authors:  M P Kaufman; D G Baker; H M Coleridge; J C Coleridge
Journal:  Circ Res       Date:  1980-04       Impact factor: 17.367

Review 10.  The sensory-efferent function of capsaicin-sensitive sensory neurons.

Authors:  C A Maggi; A Meli
Journal:  Gen Pharmacol       Date:  1988
  10 in total
  20 in total

1.  Involvement of capsaicin-sensitive neurones in the haemodynamic effects of exogenous vasoactive peptides: studies in conscious, adult Long Evans rats treated neonatally with capsaicin.

Authors:  H Bachelard; S M Gardiner; P A Kemp; T Bennett
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

2.  Calcitonin gene-related peptide in rat arterial and venous vessels: sensitivity to capsaicin, bradykinin and FMLP.

Authors:  E Del Bianco; F Perretti; M Tramontana; S Manzini; P Geppetti
Journal:  Agents Actions       Date:  1991-11

3.  Local cardiac effects of substance P: roles of acetylcholine and noradrenaline.

Authors:  H Chiao; R W Caldwell
Journal:  Br J Pharmacol       Date:  1995-01       Impact factor: 8.739

4.  Mechanism of irritant-induced cough: studies with a kinin antagonist and a kallikrein inhibitor.

Authors:  R L Featherstone; J E Parry; D M Evans; D M Jones; H Olsson; M Szelke; M K Church
Journal:  Lung       Date:  1996       Impact factor: 2.584

5.  Gastrin-releasing peptide in human nasal mucosa.

Authors:  J N Baraniuk; J D Lundgren; J Goff; D Peden; M Merida; J Shelhamer; M Kaliner
Journal:  J Clin Invest       Date:  1990-04       Impact factor: 14.808

6.  A comparison of bradykinin- and capsaicin-induced myocardial and coronary effects in isolated perfused heart of guinea-pig: involvement of substance P and calcitonin gene-related peptide release.

Authors:  S Manzini; F Perretti; L De Benedetti; P Pradelles; C A Maggi; P Geppetti
Journal:  Br J Pharmacol       Date:  1989-06       Impact factor: 8.739

7.  Multiple mechanisms in the motor responses of the guinea-pig isolated urinary bladder to bradykinin.

Authors:  C A Maggi; R Patacchini; P Santicioli; P Geppetti; R Cecconi; S Giuliani; A Meli
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

8.  Alpha-adrenoceptor modulation of the efferent function of capsaicin-sensitive sensory neurones in guinea-pig isolated atria.

Authors:  S Amerini; A Rubino; L Mantelli; F Ledda
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

9.  Formoterol and salbutamol inhibit bradykinin- and histamine-induced airway microvascular leakage in guinea-pig.

Authors:  C Advenier; Y Qian; J D Koune; M Molimard; M L Candenas; E Naline
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

10.  Influence of bradykinin in gastrointestinal disorders and visceral pain induced by acute or chronic inflammation in rats.

Authors:  V Julia; T Mezzasalma; L Buéno
Journal:  Dig Dis Sci       Date:  1995-09       Impact factor: 3.199
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