Literature DB >> 2444445

Effects of capsaicin on release of substance P-like immunoreactivity and physiological parameters in isolated perfused guinea-pig heart.

D B Hoover1.   

Abstract

Release of substance P-like immunoreactivity (SP-LI) was measured from isolated perfused guinea-pig hearts. Capsaicin (1 microM) caused a substantial increase in the amount of SP-LI detected in perfusate compared to values during exposure to vehicle or drug-free buffer. Tachyphylaxis developed to the effect of capsaicin on release of SP-LI and to its effect on physiological parameters. These data show SP-LI can be released from cardiac sensory nerves and suggest SP could mediate a portion of the response of the isolated heart to capsaicin.

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Year:  1987        PMID： 2444445     DOI： 10.1016/0014-2999(87)90571-1

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  12 in total

1.  Local cardiac effects of substance P: roles of acetylcholine and noradrenaline.

Authors:  H Chiao; R W Caldwell
Journal:  Br J Pharmacol       Date:  1995-01       Impact factor: 8.739

2.  Ruthenium-red inhibits CGRP release by capsaicin and resiniferatoxin but not by ouabain, bradykinin or nicotine in guinea-pig heart: correlation with effects on cardiac contractility.

Authors:  A Franco-Cereceda; Y P Lou; J M Lundberg
Journal:  Br J Pharmacol       Date:  1991-10       Impact factor: 8.739

3.  Simultaneous release by bradykinin of substance P- and calcitonin gene-related peptide immunoreactivities from capsaicin-sensitive structures in guinea-pig heart.

Authors:  P Geppetti; C A Maggi; F Perretti; S Frilli; S Manzini
Journal:  Br J Pharmacol       Date:  1988-06       Impact factor: 8.739

4.  A comparison of bradykinin- and capsaicin-induced myocardial and coronary effects in isolated perfused heart of guinea-pig: involvement of substance P and calcitonin gene-related peptide release.

Authors:  S Manzini; F Perretti; L De Benedetti; P Pradelles; C A Maggi; P Geppetti
Journal:  Br J Pharmacol       Date:  1989-06       Impact factor: 8.739

5.  Prostaglandins and CGRP release from cardiac sensory nerves.

Authors:  A Franco-Cereceda
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-08       Impact factor: 3.000

6.  A bradykinin (BK)1 receptor antagonist blocks capsaicin-induced ear inflammation in mice.

Authors:  C R Mantione; R Rodriguez
Journal:  Br J Pharmacol       Date:  1990-03       Impact factor: 8.739

7.  The role of substance P in myocardial dysfunction during ischemia and reperfusion.

Authors:  H Chiao; R W Caldwell
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-03       Impact factor: 3.000

8.  Effects of capsaicin desensitization on the stimulatory effect of kinins, prostaglandins, biogenic amines and various drugs in guinea-pig isolated atria.

Authors:  A Bernoussi; F Rioux
Journal:  Br J Pharmacol       Date:  1989-03       Impact factor: 8.739

9.  Actions of calcitonin gene-related peptide and tachykinins in relation to the contractile effects of capsaicin in the guinea-pig and rat heart in vitro.

Authors:  A Franco-Cereceda; J M Lundberg
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-06       Impact factor: 3.000

Review 10.  Molecular mechanism of TRP channels.

Authors:  Jie Zheng
Journal:  Compr Physiol       Date:  2013-01       Impact factor: 9.090
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