PURPOSE: To test the hypothesis that delineation of swallowing organs at risk (SWOARs) based on different guidelines results in differences in dose-volume parameters and subsequent normal tissue complication probability (NTCP) values for dysphagia-related endpoints. MATERIALS AND METHODS: Nine different SWOARs were delineated according to five different delineation guidelines in 29 patients. Reference delineation was performed according to the guidelines and NTCP-models of Christianen et al. Concordance Index (CI), dosimetric consequences, as well as differences in the subsequent NTCPs were calculated. RESULTS: The median CI of the different delineation guidelines with the reference guidelines was 0.54 for the pharyngeal constrictor muscles, 0.56 for the laryngeal structures and 0.07 for the cricopharyngeal muscle and esophageal inlet muscle. The average difference in mean dose to the SWOARs between the guidelines with the largest difference (maxΔD) was 3.5±3.2Gy. A mean ΔNTCP of 2.3±2.7% was found. For two patients, ΔNTCP exceeded 10%. CONCLUSIONS: The majority of the patients showed little differences in NTCPs between the different delineation guidelines. However, large NTCP differences >10% were found in 7% of the patients. For correct use of NTCP models in individual patients, uniform delineation guidelines are of great importance.
PURPOSE: To test the hypothesis that delineation of swallowing organs at risk (SWOARs) based on different guidelines results in differences in dose-volume parameters and subsequent normal tissue complication probability (NTCP) values for dysphagia-related endpoints. MATERIALS AND METHODS: Nine different SWOARs were delineated according to five different delineation guidelines in 29 patients. Reference delineation was performed according to the guidelines and NTCP-models of Christianen et al. Concordance Index (CI), dosimetric consequences, as well as differences in the subsequent NTCPs were calculated. RESULTS: The median CI of the different delineation guidelines with the reference guidelines was 0.54 for the pharyngeal constrictor muscles, 0.56 for the laryngeal structures and 0.07 for the cricopharyngeal muscle and esophageal inlet muscle. The average difference in mean dose to the SWOARs between the guidelines with the largest difference (maxΔD) was 3.5±3.2Gy. A mean ΔNTCP of 2.3±2.7% was found. For two patients, ΔNTCP exceeded 10%. CONCLUSIONS: The majority of the patients showed little differences in NTCPs between the different delineation guidelines. However, large NTCP differences >10% were found in 7% of the patients. For correct use of NTCP models in individual patients, uniform delineation guidelines are of great importance.
Authors: Molly K Barnhart; Bena Cartmill; Elizabeth C Ward; Elizabeth Brown; Jonathon Sim; George Saade; Sandra Rayner; Rachelle A Robinson; Virginia A Simms; Robert I Smee Journal: Dysphagia Date: 2019-02-11 Impact factor: 3.438
Authors: Jay A Messer; Abdallah S R Mohamed; Katherine A Hutcheson; Yao Ding; Jan S Lewin; Jihong Wang; Stephen Y Lai; Steven J Frank; Adam S Garden; Vlad Sandulache; Hillary Eichelberger; Chloe C French; Rivka R Colen; Jack Phan; Jayashree Kalpathy-Cramer; John D Hazle; David I Rosenthal; G Brandon Gunn; Clifton D Fuller Journal: Radiother Oncol Date: 2016-01-28 Impact factor: 6.280
Authors: Jamie A Dean; Liam C Welsh; Dualta McQuaid; Kee H Wong; Aleksandar Aleksic; Emma Dunne; Mohammad R Islam; Anushka Patel; Priyanka Patel; Imran Petkar; Iain Phillips; Jackie Sham; Kate L Newbold; Shreerang A Bhide; Kevin J Harrington; Sarah L Gulliford; Christopher M Nutting Journal: Radiother Oncol Date: 2016-03-09 Impact factor: 6.280
Authors: David Gergely Kovacs; Laura A Rechner; Ane L Appelt; Anne K Berthelsen; Junia C Costa; Jeppe Friborg; Gitte F Persson; Jens Peter Bangsgaard; Lena Specht; Marianne C Aznar Journal: Radiother Oncol Date: 2017-10-16 Impact factor: 6.280