Jayapal Ramesh1, Shantel Hebert-Magee2, Hwasoon Kim3, Jessica Trevino3, Shyam Varadarajulu4. 1. Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: j1ramesh@gmail.com. 2. Center for Interventional Endoscopy, Florida Hospital, Orlando, FL, USA; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA. 3. Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL, USA. 4. Center for Interventional Endoscopy, Florida Hospital, Orlando, FL, USA.
Abstract
BACKGROUND: Primary pancreatic lymphoma is a rare tumour of the pancreas. Data on the role of endoscopic ultrasound guided fine needle aspiration for its diagnosis are scant. AIM: To identify the frequency of occurrence, sonographic characteristics and cytological findings that are predictive of primary pancreatic lymphoma. METHODS: Pancreatic lymphoma cases were identified by retrospective review of solid pancreatic masses over 10-year period. RESULTS: 12/2397 (0.5%) lesions were identified. Patients were predominantly white (92%) and male (58%). Mean largest dimension was 47.5mm and 83.3% were located in the head. The mass appeared heterogeneous in 75% and peripancreatic lymphadenopathy was noted in 58%. None of the patients showed features of chronic pancreatitis or pancreatic ductal dilation. Rapid onsite analysis revealed atypical lymphocytes in 92%. Flow cytometry confirmed diagnosis in 75% of cases. CONCLUSIONS: Primary pancreatic lymphoma is encountered in 0.5% of patients undergoing endoscopic ultrasound guided fine needle aspiration. A large heterogeneous mass, in the absence of chronic pancreatitis or pancreatic duct dilation that reveals atypical lymphocytes on fine needle aspiration is suggestive.
BACKGROUND:Primary pancreatic lymphoma is a rare tumour of the pancreas. Data on the role of endoscopic ultrasound guided fine needle aspiration for its diagnosis are scant. AIM: To identify the frequency of occurrence, sonographic characteristics and cytological findings that are predictive of primary pancreatic lymphoma. METHODS:Pancreatic lymphoma cases were identified by retrospective review of solid pancreatic masses over 10-year period. RESULTS: 12/2397 (0.5%) lesions were identified. Patients were predominantly white (92%) and male (58%). Mean largest dimension was 47.5mm and 83.3% were located in the head. The mass appeared heterogeneous in 75% and peripancreatic lymphadenopathy was noted in 58%. None of the patients showed features of chronic pancreatitis or pancreatic ductal dilation. Rapid onsite analysis revealed atypical lymphocytes in 92%. Flow cytometry confirmed diagnosis in 75% of cases. CONCLUSIONS:Primary pancreatic lymphoma is encountered in 0.5% of patients undergoing endoscopic ultrasound guided fine needle aspiration. A large heterogeneous mass, in the absence of chronic pancreatitis or pancreatic duct dilation that reveals atypical lymphocytes on fine needle aspiration is suggestive.
Authors: Mohammad Al-Haddad; Mojgan Sara Savabi; Stuart Sherman; Lee McHenry; Julia Leblanc; Harvey Cramer; Robert Emerson; Jillian O'Neil; Mouen Khashab; John Dewitt Journal: J Gastroenterol Hepatol Date: 2009-12 Impact factor: 4.029
Authors: B Van Beers; L Lalonde; P Soyer; C Grandin; J P Trigaux; T De Ronde; C Dive; J Pringot Journal: J Comput Assist Tomogr Date: 1993 Jan-Feb Impact factor: 1.826