OBJECTIVES: Non-Hodgkin lymphoma predominantly involving the pancreas is a rare tumor and accounts for less than 0.7% of all pancreatic malignancies and 1% of extranodal lymphomas. Diagnosis of primary pancreatic lymphoma can be difficult because it may mimic carcinoma. The principal aims of this review were to highlight the difficulties encountered in making a diagnosis and to identify the role of surgery. METHODS: A PubMed search was conducted using the following terms: primary pancreatic lymphoma and non-Hodgkin lymphoma of the pancreas. Additional references were sourced from key articles. RESULTS: A total of 89 reported cases of pancreatic lymphoma between 1951 and 2005 were reviewed. An accurate preoperative diagnosis of primary pancreatic lymphoma is not always possible. A complete response rate of 100% and a long-term survival rate of 94% have been reported with surgery and adjuvant chemotherapy when compared with a 5-year survival rate of less than 50% and an overall 3-year disease-free survival rate of 44% with current chemotherapy, radiotherapy, or combined methods. CONCLUSION: Pancreaticoduodenectomy may have a therapeutic role in association with chemotherapy.
OBJECTIVES:Non-Hodgkin lymphoma predominantly involving the pancreas is a rare tumor and accounts for less than 0.7% of all pancreatic malignancies and 1% of extranodal lymphomas. Diagnosis of primary pancreatic lymphoma can be difficult because it may mimic carcinoma. The principal aims of this review were to highlight the difficulties encountered in making a diagnosis and to identify the role of surgery. METHODS: A PubMed search was conducted using the following terms: primary pancreatic lymphoma and non-Hodgkin lymphoma of the pancreas. Additional references were sourced from key articles. RESULTS: A total of 89 reported cases of pancreatic lymphoma between 1951 and 2005 were reviewed. An accurate preoperative diagnosis of primary pancreatic lymphoma is not always possible. A complete response rate of 100% and a long-term survival rate of 94% have been reported with surgery and adjuvant chemotherapy when compared with a 5-year survival rate of less than 50% and an overall 3-year disease-free survival rate of 44% with current chemotherapy, radiotherapy, or combined methods. CONCLUSION: Pancreaticoduodenectomy may have a therapeutic role in association with chemotherapy.
Authors: Riley E Alexander; Attila Nakeeb; Kumar Sandrasegaran; Michael J Robertson; Caroline An; Mohammad A Al-Haddad; Jey-Hsin Chen Journal: Gastroenterol Hepatol (N Y) Date: 2011-12
Authors: Eran Sadot; Joachim Yahalom; Richard Kinh Gian Do; Julie Teruya-Feldstein; Peter J Allen; Mithat Gönen; Michael I D'Angelica; T Peter Kingham; William R Jarnagin; Ronald P DeMatteo Journal: Ann Surg Oncol Date: 2014-10-24 Impact factor: 5.344