Reza Tabrizi1, Hooman Khorshidi2, Shoaleh Shahidi3, Mehdi Gholami4, Saman Kalbasi5, Adell Khayati6. 1. Assistant Professor, Department of Oral and Maxillofacial Surgery, Shiraz University of Medical Science School of Dentistry, Shiraz, Iran. 2. Assistant Professor, Department of Periodontology, Shiraz University of Medical Science School of Dentistry, Shiraz, Iran. 3. Associate Professor, Biomaterial Research Center, Department of Oral and Maxillofacial Radiology, Shiraz University of Medical Science School of Dentistry, Shiraz, Iran. 4. Assistant Professor, Department of Oral and Maxillofacial Surgery, North Khorasan University of Medical Science School of Dentistry, Bojnurd, Iran. Electronic address: gholami42143@yahoo.com. 5. Senior Resident, Department of Oral and Maxillofacial Surgery, Hamadan University of Medical Science School of Dentistry, Hamadan, Iran. 6. Assistant Professor, Department of Oral and Maxillofacial Surgery, Kordestan University of Medical Science, School of Dentistry, Sanandaj, Iran.
Abstract
PURPOSE: The aim of the present study was to evaluate the periodontal regenerative capacity of demineralized freeze-dried bone allograft (DFDBA) alone or used with local lincomycin. MATERIALS AND METHODS: In the present single-blind, randomized, controlled clinical trial, 20 subjects 26 years old or older, requiring extraction of bilateral third molars (M3s), were included. Each subject was randomly assigned to receive either DFDBA or DFDBA plus lincomycin therapy. Within the subjects, 1 M3 site was randomly selected to be the experimental site and the contralateral served as the control and was permitted to heal without intervention. The primary variables were changes in the probing depth (PD), clinical alveolar bone levels (ABLs), and radiographic alveolar bone density (ABD) on the distal aspect of second molar between baseline (immediately postoperatively) and 26 weeks postoperatively (T26). Appropriate sample sizes and descriptive, bivariate, and multivariate statistics were computed. RESULTS: For both treatment and control sites, between T0 and T26, statistically significant improvements were seen in the ABLs and ABD (P < .05). Within-subject comparisons showed no significant differences in PD, ABL, or ABD between the treatment and control M3 sites at T0 or T26 (P > .05). Also, no significant differences were found in the PD, ABL, or ABD between the 2 treatment M3 sites at T26 (P > .05). CONCLUSIONS: The results of the present study have revealed that the PD, ABL, and ABD improved after M3 removal in subjects 26 years old or older, irrespective of the treatment or control group. Reconstructive procedures (e.g., DFDBA with or without lincomycin therapy) did not offer predictable benefits compared with a no-treatment protocol in patients younger than 30 years old.
RCT Entities:
PURPOSE: The aim of the present study was to evaluate the periodontal regenerative capacity of demineralized freeze-dried bone allograft (DFDBA) alone or used with local lincomycin. MATERIALS AND METHODS: In the present single-blind, randomized, controlled clinical trial, 20 subjects 26 years old or older, requiring extraction of bilateral third molars (M3s), were included. Each subject was randomly assigned to receive either DFDBA or DFDBA plus lincomycin therapy. Within the subjects, 1 M3 site was randomly selected to be the experimental site and the contralateral served as the control and was permitted to heal without intervention. The primary variables were changes in the probing depth (PD), clinical alveolar bone levels (ABLs), and radiographic alveolar bone density (ABD) on the distal aspect of second molar between baseline (immediately postoperatively) and 26 weeks postoperatively (T26). Appropriate sample sizes and descriptive, bivariate, and multivariate statistics were computed. RESULTS: For both treatment and control sites, between T0 and T26, statistically significant improvements were seen in the ABLs and ABD (P < .05). Within-subject comparisons showed no significant differences in PD, ABL, or ABD between the treatment and control M3 sites at T0 or T26 (P > .05). Also, no significant differences were found in the PD, ABL, or ABD between the 2 treatment M3 sites at T26 (P > .05). CONCLUSIONS: The results of the present study have revealed that the PD, ABL, and ABD improved after M3 removal in subjects 26 years old or older, irrespective of the treatment or control group. Reconstructive procedures (e.g., DFDBA with or without lincomycin therapy) did not offer predictable benefits compared with a no-treatment protocol in patients younger than 30 years old.
Authors: Edmund Bailey; Wafa Kashbour; Neha Shah; Helen V Worthington; Tara F Renton; Paul Coulthard Journal: Cochrane Database Syst Rev Date: 2020-07-26