| Literature DB >> 24552786 |
David M Bannerman1, Rolf Sprengel2, David J Sanderson3, Stephen B McHugh1, J Nicholas P Rawlins1, Hannah Monyer4, Peter H Seeburg2.
Abstract
Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.Entities:
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Year: 2014 PMID： 24552786 DOI： 10.1038/nrn3677
Source DB: PubMed Journal: Nat Rev Neurosci ISSN： 1471-003X Impact factor: 34.870