Literature DB >> 2455255

Galanin impairs acquisition but not retrieval of spatial memory in rats studied in the Morris swim maze.

E Sundström1, T Archer, T Melander, T Hökfelt.   

Abstract

The effect of intraventricular administration of the neuropeptide galanin on acquisition and retrieval in a modified Morris swim maze was studied in rats. Galanin induced a significant deficit in the acquisition of the task while no effects on the retrieval were observed. No deficits were seen 24 h after the last treatment. Galanin did not increase the number of failures to reach the platform. It is suggested that endogenous galanin modulates learning possibly via the galanin-containing cholinergic neurons in the septum-basal forebrain area projecting to the hippocampus and cortex.

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Year:  1988        PMID： 2455255     DOI： 10.1016/0304-3940(88)90233-9

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  20 in total

1.  Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease.

Authors:  R A Steiner; J G Hohmann; A Holmes; C C Wrenn; G Cadd; A Juréus; D K Clifton; M Luo; M Gutshall; S Y Ma; E J Mufson; J N Crawley
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-20       Impact factor: 11.205

2.  CSF galanin and cognition after shunt surgery in normal pressure hydrocephalus.

Authors:  M Mataró; M A Poca; M Del Mar Matarín; R Catalan; J Sahuquillo; R Galard
Journal:  J Neurol Neurosurg Psychiatry       Date:  2003-09       Impact factor: 10.154

3.  Galanin receptor subtype 2 (GalR2) null mutant mice display an anxiogenic-like phenotype specific to the elevated plus-maze.

Authors:  Kathleen R Bailey; Maria N Pavlova; Alex D Rohde; John G Hohmann; Jacqueline N Crawley
Journal:  Pharmacol Biochem Behav       Date:  2007-01-25       Impact factor: 3.533

4.  Influence of the neuropeptide galanin on active avoidance in rats.

Authors:  A A Shandra; A M Mazarati; K L Servetskii
Journal:  Neurosci Behav Physiol       Date:  1994 Sep-Oct

5.  M-15: high-affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus, locus coeruleus, and spinal cord.

Authors:  T Bartfai; K Bedecs; T Land; U Langel; R Bertorelli; P Girotti; S Consolo; X J Xu; Z Wiesenfeld-Hallin; S Nilsson
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-01       Impact factor: 11.205

6.  Galanin receptor-mediated inhibition of glutamate release in the arcuate nucleus of the hypothalamus.

Authors:  G A Kinney; P J Emmerson; R J Miller
Journal:  J Neurosci       Date:  1998-05-15       Impact factor: 6.167

7.  N-terminal galanin-(1-16) fragment is an agonist at the hippocampal galanin receptor.

Authors:  G Fisone; M Berthold; K Bedecs; A Undén; T Bartfai; R Bertorelli; S Consolo; J Crawley; B Martin; S Nilsson
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

8.  Galanin modulation of seizures and seizure modulation of hippocampal galanin in animal models of status epilepticus.

Authors:  A M Mazarati; H Liu; U Soomets; R Sankar; D Shin; H Katsumori; U Langel; C G Wasterlain
Journal:  J Neurosci       Date:  1998-12-01       Impact factor: 6.167

9.  Deficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic mice.

Authors:  Jefferson W Kinney; Grzegorz Starosta; Andrew Holmes; Craige C Wrenn; Rebecca J Yang; Ashley P Harris; Katharine C Long; Jacqueline N Crawley
Journal:  Learn Mem       Date:  2002 Jul-Aug       Impact factor: 2.460

10.  Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures.

Authors:  Robert P Lisak; Joyce A Benjamins; Beverly Bealmear; Liljana Nedelkoska; Diane Studzinski; Ernest Retland; Bin Yao; Susan Land
Journal:  J Neuroinflammation       Date:  2009-01-21       Impact factor: 8.322
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