Practical approach for asymmetric hydroxyamination of aldehydes with in situ generated nitrosocarbonyl compounds: application to one-pot synthesis of chiral allylamines.

The highly regio- and enantioselective hydroxyamination of aldehydes with in situ generated nitrosocarbonyl compounds from a hydroxamic acid derivative was realized by simple and readily available chiral amine catalysts. The resulting hydroxyamination products were readily converted to the corresponding chiral 1,2-aminoalcohol or allylamine derivatives in one pot.