Literature DB >> 24550373

Accelerated suppression of primary Epstein-Barr virus infection in HIV-infected infants initiating lopinavir/ritonavir-based versus nevirapine-based combination antiretroviral therapy.

Jennifer A Slyker1, Corey Casper, Kenneth Tapia, Barbra Richardson, Lisa Bunts, Meei-Li Huang, Dalton Wamalwa, Sarah Benki-Nugent, Grace John-Stewart.   

Abstract

We compared primary Epstein-Barr virus (EBV) infection and suppression between Kenyan human immunodeficiency virus-infected infants starting nevirapine-based vs lopinavir/ritonavir-based antiretroviral regimens. Although the rate of EBV infection was similar between groups, infants receiving lopinavir/ritonavir suppressed EBV more rapidly. Our findings suggest that specific antiretrovirals may potentially impact the risk of future EBV-associated malignancies.

Entities:  

Keywords:  Epstein-Barr virus; HIV; antiretroviral therapy; infant; primary infection

Mesh：

Substances：

Year:  2014        PMID： 24550373      PMCID： PMC3982841          DOI： 10.1093/cid/ciu088

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  14 in total

1.  Primary Epstein-Barr virus infections in African infants. I. Decline of maternal antibodies and time of infection.

Authors:  R J Biggar; W Henle; G Fleisher; J Böcker; E T Lennette; G Henle
Journal:  Int J Cancer       Date:  1978-09-15       Impact factor: 7.396

2.  B-cell stimulation and prolonged immune deficiency are risk factors for non-Hodgkin's lymphoma in people with AIDS.

Authors:  A E Grulich; X Wan; M G Law; S T Milliken; C R Lewis; R J Garsia; J Gold; R J Finlayson; D A Cooper; J M Kaldor
Journal:  AIDS       Date:  2000-01-28       Impact factor: 4.177

3.  Dynamics of Epstein-Barr virus in HIV-1-infected subjects on highly active antiretroviral therapy.

Authors:  Elisabetta Righetti; Gianna Ballon; Lucia Ometto; Anna Maria Cattelan; Chiara Menin; Marisa Zanchetta; Luigi Chieco-Bianchi; Anita De Rossi
Journal:  AIDS       Date:  2002-01-04       Impact factor: 4.177

Review 4.  Human herpesvirus 8-associated neoplasms: the roles of viral replication and antiviral treatment.

Authors:  Soren Gantt; Corey Casper
Journal:  Curr Opin Infect Dis       Date:  2011-08       Impact factor: 4.915

5.  Epstein-Barr virus (EBV) infection in infancy.

Authors:  K H Chan; J S Tam; J S Peiris; W H Seto; M H Ng
Journal:  J Clin Virol       Date:  2001-04       Impact factor: 3.168

6.  Survival benefit of early infant antiretroviral therapy is compromised when diagnosis is delayed.

Authors:  Dalton Wamalwa; Sarah Benki-Nugent; Agnes Langat; Ken Tapia; Evelyn Ngugi; Jennifer A Slyker; Barbra A Richardson; Grace C John-Stewart
Journal:  Pediatr Infect Dis J       Date:  2012-07       Impact factor: 2.129

7.  B-cell stimulatory cytokines and markers of immune activation are elevated several years prior to the diagnosis of systemic AIDS-associated non-Hodgkin B-cell lymphoma.

Authors:  Elizabeth Crabb Breen; Shehnaz K Hussain; Larry Magpantay; Lisa P Jacobson; Roger Detels; Charles S Rabkin; Richard A Kaslow; Daina Variakojis; Jay H Bream; Charles R Rinaldo; Richard F Ambinder; Otoniel Martinez-Maza
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2011-04-28       Impact factor: 4.254

8.  Malignancy in perinatally human immunodeficiency virus-infected children in the United States.

Authors:  Helen Kest; Susan Brogly; George McSherry; Barry Dashefsky; James Oleske; George R Seage
Journal:  Pediatr Infect Dis J       Date:  2005-03       Impact factor: 2.129

9.  Clinical and virologic manifestations of primary Epstein-Barr virus (EBV) infection in Kenyan infants born to HIV-infected women.

Authors:  Jennifer A Slyker; Corey Casper; Kenneth Tapia; Barbra Richardson; Lisa Bunts; Meei-Li Huang; Elizabeth Maleche-Obimbo; Ruth Nduati; Grace John-Stewart
Journal:  J Infect Dis       Date:  2013-03-14       Impact factor: 5.226

10.  An HIV protease inhibitor, ritonavir targets the nuclear factor-kappaB and inhibits the tumor growth and infiltration of EBV-positive lymphoblastoid B cells.

Authors:  Md Zahidunnabi Dewan; Mariko Tomita; Harutaka Katano; Norio Yamamoto; Sunjida Ahmed; Michiko Yamamoto; Tetsutaro Sata; Naoki Mori; Naoki Yamamoto
Journal:  Int J Cancer       Date:  2009-02-01       Impact factor: 7.396
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  1 in total

1.  Congenital and postnatal CMV and EBV acquisition in HIV-infected Zimbabwean infants.

Authors:  Hlanai Gumbo; Bernard Chasekwa; James A Church; Robert Ntozini; Kuda Mutasa; Jean H Humphrey; Andrew J Prendergast
Journal:  PLoS One       Date:  2014-12-18       Impact factor: 3.240
  1 in total

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