Literature DB >> 24550324

Trichomonas vaginalis metronidazole resistance is associated with single nucleotide polymorphisms in the nitroreductase genes ntr4Tv and ntr6Tv.

Teresa E Paulish-Miller1, Peter Augostini, Jessica A Schuyler, William L Smith, Eli Mordechai, Martin E Adelson, Scott E Gygax, William E Secor, David W Hilbert.   

Abstract

Metronidazole resistance in the sexually transmitted parasite Trichomonas vaginalis is a problematic public health issue. We have identified single nucleotide polymorphisms (SNPs) in two nitroreductase genes (ntr4Tv and ntr6Tv) associated with resistance. These SNPs were associated with one of two distinct T. vaginalis populations identified by multilocus sequence typing, yet one SNP (ntr6Tv A238T), which results in a premature stop codon, was associated with resistance independent of population structure and may be of diagnostic value.

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Year:  2014        PMID： 24550324      PMCID： PMC3993245          DOI： 10.1128/AAC.02370-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Utility of antimicrobial susceptibility testing in Trichomonas vaginalis-infected women with clinical treatment failure.

Authors:  Elizabeth A Bosserman; Donna J Helms; Debra J Mosure; W Evan Secor; Kimberly A Workowski
Journal:  Sex Transm Dis       Date:  2011-10       Impact factor: 2.830

2.  The establishment of various trichomonads of animals and man in axenic cultures.

Authors:  L S DIAMOND
Journal:  J Parasitol       Date:  1957-08       Impact factor: 1.276

3.  Mycoplasma hominis infection of Trichomonas vaginalis is not associated with metronidazole-resistant trichomoniasis in clinical isolates from the United States.

Authors:  Sara E Butler; Peter Augostini; W Evan Secor
Journal:  Parasitol Res       Date:  2010-07-21       Impact factor: 2.289

4.  Molecular epidemiology of metronidazole resistance in a population of Trichomonas vaginalis clinical isolates.

Authors:  L J Snipes; P M Gamard; E M Narcisi; C B Beard; T Lehmann; W E Secor
Journal:  J Clin Microbiol       Date:  2000-08       Impact factor: 5.948

5.  Symbiosis of Mycoplasma hominis in Trichomonas vaginalis may link metronidazole resistance in vitro.

Authors:  J C Xiao; L F Xie; S L Fang; M Y Gao; Y Zhu; L Y Song; H M Zhong; Z R Lun
Journal:  Parasitol Res       Date:  2006-07-18       Impact factor: 2.289

6.  Inferring weak population structure with the assistance of sample group information.

Authors:  Melissa J Hubisz; Daniel Falush; Matthew Stephens; Jonathan K Pritchard
Journal:  Mol Ecol Resour       Date:  2009-04-01       Impact factor: 7.090

7.  Hydrogenosomes of laboratory-induced metronidazole-resistant Trichomonas vaginalis lines are downsized while those from clinically metronidazole-resistant isolates are not.

Authors:  Janelle M Wright; Richard I Webb; Peter O'Donoghue; Peter Upcroft; Jacqueline A Upcroft
Journal:  J Eukaryot Microbiol       Date:  2009-12-10       Impact factor: 3.346

8.  Genetic characterization of Trichomonas vaginalis isolates by use of multilocus sequence typing.

Authors:  Denise C Cornelius; D Ashley Robinson; Christina A Muzny; Leandro A Mena; David M Aanensen; William B Lushbaugh; John C Meade
Journal:  J Clin Microbiol       Date:  2012-08-01       Impact factor: 5.948

9.  Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis.

Authors:  Jane M Carlton; Robert P Hirt; Joana C Silva; Arthur L Delcher; Michael Schatz; Qi Zhao; Jennifer R Wortman; Shelby L Bidwell; U Cecilia M Alsmark; Sébastien Besteiro; Thomas Sicheritz-Ponten; Christophe J Noel; Joel B Dacks; Peter G Foster; Cedric Simillion; Yves Van de Peer; Diego Miranda-Saavedra; Geoffrey J Barton; Gareth D Westrop; Sylke Müller; Daniele Dessi; Pier Luigi Fiori; Qinghu Ren; Ian Paulsen; Hanbang Zhang; Felix D Bastida-Corcuera; Augusto Simoes-Barbosa; Mark T Brown; Richard D Hayes; Mandira Mukherjee; Cheryl Y Okumura; Rachel Schneider; Alias J Smith; Stepanka Vanacova; Maria Villalvazo; Brian J Haas; Mihaela Pertea; Tamara V Feldblyum; Terry R Utterback; Chung-Li Shu; Kazutoyo Osoegawa; Pieter J de Jong; Ivan Hrdy; Lenka Horvathova; Zuzana Zubacova; Pavel Dolezal; Shehre-Banoo Malik; John M Logsdon; Katrin Henze; Arti Gupta; Ching C Wang; Rebecca L Dunne; Jacqueline A Upcroft; Peter Upcroft; Owen White; Steven L Salzberg; Petrus Tang; Cheng-Hsun Chiu; Ying-Shiung Lee; T Martin Embley; Graham H Coombs; Jeremy C Mottram; Jan Tachezy; Claire M Fraser-Liggett; Patricia J Johnson
Journal:  Science       Date:  2007-01-12       Impact factor: 47.728

10.  Down-regulation of flavin reductase and alcohol dehydrogenase-1 (ADH1) in metronidazole-resistant isolates of Trichomonas vaginalis.

Authors:  David Leitsch; Mirjana Drinić; Daniel Kolarich; Michael Duchêne
Journal:  Mol Biochem Parasitol       Date:  2012-03-17       Impact factor: 1.759
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  23 in total

1.  The genetic diversity of metronidazole susceptibility in Trichomonas vaginalis clinical isolates in an Egyptian population.

Authors:  Aida A Abdel-Magied; El-Said I El-Kholya; Salwa M Abou El-Khair; Eman S Abdelmegeed; Marwa M Hamoudaa; Sara A Mohamed; Nora Labeeb El-Tantawy
Journal:  Parasitol Res       Date:  2017-09-27       Impact factor: 2.289

Review 2.  Strategies for Prevention and Treatment of Trichomonas vaginalis Infections.

Authors:  Kawthar Bouchemal; Christian Bories; Philippe M Loiseau
Journal:  Clin Microbiol Rev       Date:  2017-07       Impact factor: 26.132

3.  2'-Hydroxychalcones as an alternative treatment for trichomoniasis in association with metronidazole.

Authors:  Raquel Nascimento das Neves; Ângela Sena-Lopes; Mirna Samara Dié Alves; Bárbara da Rocha Fonseca; Caroline Carapina da Silva; Angela Maria Casaril; Lucielli Savegnago; Claudio Martin Pereira de Pereira; Daniela Fernandes Ramos; Sibele Borsuk
Journal:  Parasitol Res       Date:  2019-12-18       Impact factor: 2.289

4.  A systematic review of the literature on mechanisms of 5-nitroimidazole resistance in Trichomonas vaginalis.

Authors:  Keonte J Graves; Jan Novak; W Evan Secor; Patricia J Kissinger; Jane R Schwebke; Christina A Muzny
Journal:  Parasitology       Date:  2020-07-30       Impact factor: 3.234

5.  Effects of amiodarone, amioder, and dronedarone on Trichomonas vaginalis.

Authors:  Tatiana Guinancio de Souza; Gustavo Benaim; Wanderley de Souza; Marlene Benchimol
Journal:  Parasitol Res       Date:  2022-04-18       Impact factor: 2.289

Review 6.  Long non-coding RNAs as possible therapeutic targets in protozoa, and in Schistosoma and other helminths.

Authors:  Gilbert O Silveira; Helena S Coelho; Murilo S Amaral; Sergio Verjovski-Almeida
Journal:  Parasitol Res       Date:  2021-12-03       Impact factor: 2.289

7.  Anti-parasitic activity of nano Citrullus colocynthis and nano Capparis spinose against Trichomonas vaginalis in vitro.

Authors:  Musafer H Al-Ardi
Journal:  J Parasit Dis       Date:  2021-03-13

8.  Detection of metronidazole resistance in Trichomonas vaginalis using uncultured vaginal swabs.

Authors:  Bongekile Ngobese; Ravesh Singh; Khine Swe Swe- Han; Partson Tinarwo; Nonkululeko Mabaso; Nathlee S Abbai
Journal:  Parasitol Res       Date:  2022-06-03       Impact factor: 2.383

Review 9.  Recent Advances in the Trichomonas vaginalis Field.

Authors:  David Leitsch
Journal:  F1000Res       Date:  2016-02-11

10.  Multilocus sequence typing of Trichomonas vaginalis clinical samples from Amsterdam, the Netherlands.

Authors:  C van der Veer; M Himschoot; S M Bruisten
Journal:  BMJ Open       Date:  2016-10-13       Impact factor: 2.692
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