Literature DB >> 2454844

Is translation inhibited by noncognate ternary complexes?

N Bilgin1, M Ehrenberg, C Kurland.   

Abstract

We studied the influence of an error-prone isoacceptor (tRNALeu4), as well as an intermediate (tRNALeu2) and a weak (tRNAVal) competitor of tRNAPhe on the poly(Phe) synthesis rate. Even at very high excess concentrations of these noncognate ternary complexes there was no significant effect on the translation rate. Our result argues against the assertion that in vivo translation is slowed down by noncognate tRNA and favours the hypothesis that the incorrect ternary complex concentrations are too low to saturate the ribosomes in vivo.

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Year:  1988        PMID： 2454844     DOI： 10.1016/0014-5793(88)81362-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  Dynamics and efficiency in vivo of UGA-directed selenocysteine insertion at the ribosome.

Authors:  S Suppmann; B C Persson; A Böck
Journal:  EMBO J       Date:  1999-04-15       Impact factor: 11.598

Review 2.  Evolutionary optimization of speed and accuracy of decoding on the ribosome.

Authors:  Ingo Wohlgemuth; Corinna Pohl; Joerg Mittelstaet; Andrey L Konevega; Marina V Rodnina
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2011-10-27       Impact factor: 6.237

3.  Optimization of speed and accuracy of decoding in translation.

Authors:  Ingo Wohlgemuth; Corinna Pohl; Marina V Rodnina
Journal:  EMBO J       Date:  2010-09-14       Impact factor: 11.598

4.  The selection-mutation-drift theory of synonymous codon usage.

Authors:  M Bulmer
Journal:  Genetics       Date:  1991-11       Impact factor: 4.562

5.  Effects of codon distributions and tRNA competition on protein translation.

Authors:  Hermioni Zouridis; Vassily Hatzimanikatis
Journal:  Biophys J       Date:  2008-03-21       Impact factor: 4.033

Review 6.  Codon preferences in free-living microorganisms.

Authors:  S G Andersson; C G Kurland
Journal:  Microbiol Rev       Date:  1990-06

7.  How optimized is the translational machinery in Escherichia coli, Salmonella typhimurium and Saccharomyces cerevisiae?

Authors:  X Xia
Journal:  Genetics       Date:  1998-05       Impact factor: 4.562

8.  Polyamines accelerate codon recognition by transfer RNAs on the ribosome.

Authors:  Byron Hetrick; Prashant K Khade; Kristin Lee; Jenise Stephen; Alex Thomas; Simpson Joseph
Journal:  Biochemistry       Date:  2010-08-24       Impact factor: 3.162

9.  Biochemical evidence of translational infidelity and decreased peptidyltransferase activity by a sarcin/ricin domain mutation of yeast 25S rRNA.

Authors:  Panagiotis Panopoulos; John Dresios; Dennis Synetos
Journal:  Nucleic Acids Res       Date:  2004-10-11       Impact factor: 16.971

10.  Significance of the third tRNA binding site, the E site, on E. coli ribosomes for the accuracy of translation: an occupied E site prevents the binding of non-cognate aminoacyl-tRNA to the A site.

Authors:  U Geigenmüller; K H Nierhaus
Journal:  EMBO J       Date:  1990-12       Impact factor: 11.598
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