Shinjita Das1, Ira Bernstein2, Heidi Jacobe3. 1. Department of Dermatology, Harvard Medical School, Boston, Massachusetts. 2. Department of Biostatistics and Clinical Science, University of Texas Southwestern Medical Center, Dallas, Texas. 3. Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address: heidi.jacobe@utsouthwestern.edu.
Abstract
BACKGROUND: Determining a disease's impact on life quality is important in clinical decision making, research, and resource allocation. Determinants of quality of life (QOL) in morphea are poorly understood. OBJECTIVE: We sought to ascertain demographic and clinical variables correlated with negative impact on self-reported QOL in morphea. METHODS: We conducted a cross-sectional survey of the Morphea in Adults and Children cohort. RESULTS: Symptoms (pruritus and pain) and functional impairment were correlated with decreased QOL in children and adults. This was true in both sexes and was independent of subtype and age. Patient-reported QOL correlated with physician-based measures of disease severity in adults, but not in children. Patients with linear and generalized morphea had the greatest impact on QOL. LIMITATIONS: Small sample size is a limitation. CONCLUSION: Symptoms and functional impairment were determinants of impaired life quality in both children and adults independent of morphea subtype. These results suggest that clinicians should consider suppressing the accumulation of new lesions (when rapidly accumulating) and symptoms (pain and pruritus) in the treatment of patients with morphea.
BACKGROUND: Determining a disease's impact on life quality is important in clinical decision making, research, and resource allocation. Determinants of quality of life (QOL) in morphea are poorly understood. OBJECTIVE: We sought to ascertain demographic and clinical variables correlated with negative impact on self-reported QOL in morphea. METHODS: We conducted a cross-sectional survey of the Morphea in Adults and Children cohort. RESULTS: Symptoms (pruritus and pain) and functional impairment were correlated with decreased QOL in children and adults. This was true in both sexes and was independent of subtype and age. Patient-reported QOL correlated with physician-based measures of disease severity in adults, but not in children. Patients with linear and generalized morphea had the greatest impact on QOL. LIMITATIONS: Small sample size is a limitation. CONCLUSION: Symptoms and functional impairment were determinants of impaired life quality in both children and adults independent of morphea subtype. These results suggest that clinicians should consider suppressing the accumulation of new lesions (when rapidly accumulating) and symptoms (pain and pruritus) in the treatment of patients with morphea.
Authors: D E Furst; P J Clements; V D Steen; T A Medsger; A T Masi; W A D'Angelo; P A Lachenbruch; R G Grau; J R Seibold Journal: J Rheumatol Date: 1998-01 Impact factor: 4.666
Authors: Tamás Constantin; Ivan Foeldvari; Clare E Pain; Annamária Pálinkás; Peter Höger; Monika Moll; Dana Nemkova; Lisa Weibel; Melinda Laczkovszki; Philip Clements; Kathryn S Torok Journal: Eur J Pediatr Date: 2018-05-04 Impact factor: 3.183
Authors: Kathryn S Torok; Katherine Kurzinski; Christina Kelsey; Jonathan Yabes; Kelsey Magee; Abbe N Vallejo; Thomas Medsger; Carol A Feghali-Bostwick Journal: Semin Arthritis Rheum Date: 2015-06-17 Impact factor: 5.532