Dong Yeob Shin1, Kwang Joon Kim, Daham Kim, Sena Hwang, Eun Jig Lee. 1. Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. ejlee423@yuhs.ac.
Abstract
PURPOSE: The association between autoimmune thyroid diseases (AITDs) and vitamin D deficiency is controversial. We aimed to evaluate the relationship between serum 25-hydroxy-vitamin D3 [25(OH)D3] and anti-thyroid antibody levels. MATERIALS AND METHODS: 25(OH)D3, anti-thyroid antibodies, and thyroid function measured in 304 patients who visited the endocrinology clinic were analyzed. The patients were subgrouped into the AITDs or non-AITDs category according to the presence or absence of anti-thyroid antibodies. The relationship between anti-thyroid peroxidase antibody (TPOAb) and 25(OH)D3 was evaluated. RESULTS: The patients with elevated anti-thyroid antibodies had lower levels of serum 25(OH)D3 than those who did not (12.6±5.5 ng/mL vs. 14.5±7.3 ng/mL, respectively, p<0.001). Importantly, after adjusting for age, sex, and body mass index, a negative correlation (r=-0.252, p<0.001) was recognized between 25(OH)D3 and TPOAb levels in the AITDs group, but this correlation did not exist in the non-AITDs group (r=0.117, p=0.127). 25(OH)D3 level was confirmed as an independent factor after adjusting for co-factors that may affect the presence of TPOAb in the AITDs group. CONCLUSION: 25(OH)D3 level is an independent factor affecting the presence of TPOAb in AITDs. The causal effect of 25(OH)D3 deficiency to AITDs is to be elucidated.
PURPOSE: The association between autoimmune thyroid diseases (AITDs) and vitamin D deficiency is controversial. We aimed to evaluate the relationship between serum 25-hydroxy-vitamin D3 [25(OH)D3] and anti-thyroid antibody levels. MATERIALS AND METHODS:25(OH)D3, anti-thyroid antibodies, and thyroid function measured in 304 patients who visited the endocrinology clinic were analyzed. The patients were subgrouped into the AITDs or non-AITDs category according to the presence or absence of anti-thyroid antibodies. The relationship between anti-thyroid peroxidase antibody (TPOAb) and 25(OH)D3 was evaluated. RESULTS: The patients with elevated anti-thyroid antibodies had lower levels of serum 25(OH)D3 than those who did not (12.6±5.5 ng/mL vs. 14.5±7.3 ng/mL, respectively, p<0.001). Importantly, after adjusting for age, sex, and body mass index, a negative correlation (r=-0.252, p<0.001) was recognized between 25(OH)D3 and TPOAb levels in the AITDs group, but this correlation did not exist in the non-AITDs group (r=0.117, p=0.127). 25(OH)D3 level was confirmed as an independent factor after adjusting for co-factors that may affect the presence of TPOAb in the AITDs group. CONCLUSION:25(OH)D3 level is an independent factor affecting the presence of TPOAb in AITDs. The causal effect of 25(OH)D3 deficiency to AITDs is to be elucidated.
Entities:
Keywords:
Vitamin D deficiency; anti-thyroid peroxidase antibody; autoimmune thyroiditis
Authors: Diane L Kamen; Glinda S Cooper; Henda Bouali; Stephanie R Shaftman; Bruce W Hollis; Gary S Gilkeson Journal: Autoimmun Rev Date: 2005-06-21 Impact factor: 9.754
Authors: M R Haussler; G K Whitfield; C A Haussler; J C Hsieh; P D Thompson; S H Selznick; C E Dominguez; P W Jurutka Journal: J Bone Miner Res Date: 1998-03 Impact factor: 6.741
Authors: Astrid G S van Halteren; Odette M Tysma; Evelyne van Etten; Chantal Mathieu; Bart O Roep Journal: J Autoimmun Date: 2004-11 Impact factor: 7.094
Authors: Astrid G S van Halteren; Evelyne van Etten; Esther C de Jong; Roger Bouillon; Bart O Roep; Chantal Mathieu Journal: Diabetes Date: 2002-07 Impact factor: 9.461
Authors: G Muscogiuri; G Tirabassi; G Bizzaro; F Orio; S A Paschou; A Vryonidou; G Balercia; Y Shoenfeld; A Colao Journal: Eur J Clin Nutr Date: 2014-12-17 Impact factor: 4.016
Authors: Aniceta A Mikulska; Marta Karaźniewicz-Łada; Dorota Filipowicz; Marek Ruchała; Franciszek K Główka Journal: Int J Mol Sci Date: 2022-06-13 Impact factor: 6.208
Authors: D Gallo; L Mortara; M B Gariboldi; S A M Cattaneo; S Rosetti; L Gentile; D M Noonan; P Premoli; C Cusini; M L Tanda; L Bartalena; E Piantanida Journal: J Endocrinol Invest Date: 2019-10-04 Impact factor: 5.467