Literature DB >> 2452890

Enhancement of natural killer activity in human peripheral blood by flavone acetic acid.

W J Urba1, D L Longo, F A Lombardo, R B Weiss.   

Abstract

Natural killer cell activity and interferon (IFN) production were measured in 6 patients receiving flavone acetic acid for treatment of cancer. Natural killer cell activity was significantly increased in 3 of 6 patients receiving 6.4 g of flavone acetic acid/m2 by 3-hour iv infusion. Analysis of cell surface markers failed to reveal significant changes in any cell population. There was no evidence of induction of IFN-gamma, but 3 of 4 patients tested had evidence of induction of type I IFN, as measured in a virus neutralization assay.

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Year:  1988        PMID： 2452890     DOI： 10.1093/jnci/80.7.521

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   13.506


  11 in total

1.  Flavone acetic acid antitumour activity against a mouse pancreatic adenocarcinoma is mediated by natural killer cells.

Authors:  G Damia; G Tagliabue; P Allavena; M D'Incalci
Journal:  Cancer Immunol Immunother       Date:  1990       Impact factor: 6.968

2.  A phase I and pharmacokinetic study of 12-h infusion of flavone acetic acid.

Authors:  I N Olver; L K Webster; J F Bishop; K H Stokes
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

Review 3.  Flavone 8-acetic acid: our current understanding of its mechanism of action in solid tumours.

Authors:  J Cummings; J F Smyth
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

4.  Flavone acetic acid (LM-975; NSC-347512) activation to cytotoxic species in vivo and in vitro.

Authors:  G G Chabot; M C Bissery; A Gouyette
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

5.  Flavone acetic acid distribution in human malignant tumors.

Authors:  G Damia; A Freschi; R Sorio; A Braida; G Caruso; M Quaia; S Monfardini; M D'Incalci
Journal:  Cancer Chemother Pharmacol       Date:  1990       Impact factor: 3.333

6.  Flavone acetic acid--an interesting novel therapeutic agent or just another disappointment?

Authors:  M C Bibby
Journal:  Br J Cancer       Date:  1991-01       Impact factor: 7.640

7.  Flavone acetic acid (FAA) with recombinant interleukin-2 (rIL-2) in advanced malignant melanoma. III: Cytokine studies.

Authors:  C Haworth; S M O'Reilly; E Chu; G J Rustin; M Feldmann
Journal:  Br J Cancer       Date:  1993-06       Impact factor: 7.640

8.  Recombinant interleukin-2 (rIL-2) with flavone acetic acid (FAA) in advanced malignant melanoma: immunological studies.

Authors:  A K Ghosh; M Mellor; J Prendiville; N Thatcher
Journal:  Br J Cancer       Date:  1990-03       Impact factor: 7.640

9.  Tumour concentrations of flavone acetic acid (FAA) in human melanoma: comparison with mouse data.

Authors:  T S Maughan; R Ward; I Dennis; D J Honess; P Workman; N M Bleehen
Journal:  Br J Cancer       Date:  1992-09       Impact factor: 7.640

10.  Flavone acetic acid (FAA) with recombinant interleukin-2 (TIL-2) in advanced malignant melanoma. II: Induction of nitric oxide production.

Authors:  L L Thomsen; B C Baguley; G J Rustin; S M O'Reilly
Journal:  Br J Cancer       Date:  1992-10       Impact factor: 7.640
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